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Journal of Drug Delivery and Therapeutics

Open Access to Pharmaceutical and Medical Research

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Open Access   Full Text Article                                                                                                                                                                         Research Article 

Formulation and Evaluation of Polyherbal Cream

Vibhavari M. Chatur*, Nazma M. Ansari, Sanket K. Joshi, Sanjay G. Walode

Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Pune-19, India

INTRODUCTION

Cream formulation was semisolid formulations intended for topical application. The cream formulations were prepared by using various herbal extracts, herbal oils, and various excipients. 

Cosmetic products are used for the protection of skin from various endogenous and exogenous harmful agents along with enhancing the beauty and making skin attractive.¹ The only use of cosmetic is not developing an attractive external appearance but also achieving longevity of good health by reducing skin disorders.² The cosmetics which are meant for skin care nourishes the health, texture and moisturizes the skin. ³

Polyherbal cream is a semisolid formulation intended for topical application. The cream formulation is prepared by using various herbal extracts, almond oil and various excipients^{. 4}

Nyctanthes arbor-tristis was the oldest holistic, sacred and traditional medicinal plant belongs to family Oleaceae. The plant was mentioned in Vishnu Purana and having great importance to treat varieties of diseases, especially rheumatoid arthritis it reduces pain and inflammation ⁷. The fresh leaves are collected and complete shade drying, further powdered by using the mixer. This formed powder was passed through the sieve. The extract was obtained by using a simple maceration process. 

Maceration was extractive technique and carried out at roomtemperature.  Powdered herbal leaves of Nyctanthes arbor-tristis wasimmersed in alcohol and continuousshacking byusing REMI RSB  12 mechanical shaker. After 3 d the concentrated extract was collected and filtered. 

Nyctanthes arbor-tristis is an old holistic, sacred and traditional medicinal plant belonging to family Oleaceae. The fresh leaves were collected and dried in shade, further powdered by using the mixer. This formed powder was passed through the sieve. The extract was obtained by using a simple maceration process. ⁵

Almond oil has excellent emollientproperties help the skin to balance water loss andabsorption of moisture, helps relieve irritation, inflammation and itching, and is greatly lubricating.⁶

Gram flour, commonly known as Besan, has been used extensively since the olden times for its beauty-enhancing benefits. It mainly acts as a tonic for the skin as it helps to clean and exfoliate it. ⁷

The secondary metabolites which are present in the plants taken will support the strength, texture and integrity to skin along with the moisturizing of skin and maintaining its elasticity.⁸ Thus, the presence of herbal ingredients in skincare formulation helps reduce the production of free radicals in the skin and maintain for a long time.Active ingredients delays skin aging by reducing the wrinkles, protect against UV radiation by antioxidant property.⁹

MATERIAL AND METHODS

Table 1: Ingredients used for the formulation of Polyherbal Cream

2. Method for preparation of Polyherbal Cream-^[12]
3. Add the required quantity of Borax in sufficient amount of water and prepare a solution by heating on water bath.
4. In the above solution, add required quantity of night jasmine, neem extract and besan powder. [Solution 1]
5. Weigh accurately almond oil and add into beeswax contained in a china dish, melt to prepare a proper solution. [Solution 2]
6. Add Solution1 dropwise into Solution2. When both the phases get mixed properly, add methyl paraben as preservative.
7. The formulated Polyherbal Cream was kept aside for about an hour in cool and dry place indirect to sunlight till it sets completely and was used after 48 hours after keeping at room temperature for stability and analytical testing.

Table 2: Composition of Polyherbal Cream

Formulated polyherbal Cream

Evaluation of Polyherbal Cream^-

The evaluation of herbal cream was following.  

Formulated herbal cream was further evaluated by using the following physical parameters: Color, Odour, Consistency, and state of the formulation. 

a) Colour:The colour of the cream wasobserved by visual examination. 

b) Odour: The odour of cream was found to be characteristics. 

c) Consistency: The formulation was examined by rubbing cream on hand manually. The cream having smooth consistency. Cream did not leave greasy substances on skin surface after application. 

d) State:  The state of cream was examined visually.  The cream having a semisolid state. 

e) pH-The pHof prepared herbal cream was measured by using digital pH meter.  The solution of cream was prepared by using 100 ml of distilled water and set aside for 2 h.

Spreadability of formulated cream was measured by placing sample in between two slides then compressed to uniform thickness by placing a definite weight for a definite time.  The specified time required to separate the two slides was measured as spreadability. 

Spreadability was calculated by the following formula:  

Formula-

Where,

S= Spreadability 

M= Weight tide to the upper slide 

L= Length of glass slide 

T= Time taken to separate the slides. 

Formulation was applied on the skin and then ease extends of washing with water was checked. ¹²

Herbal cream formulation was evaluated for the non-irritancy test. Observation of the sites was done for 24 h. ¹⁵

Viscosity 

Viscosity of cream was done by using Brooke field viscometer at the temp of 25 °C using spindle no.  63 at 5rpm. Results were shown in table 2. 

Phase separation 

The prepared cream was transferried in a suitable wide mouth h contrainner. Set asidefor story age, the oil phase and aqueous phase separationn was visualizing after   24h.   R results were shown in table 2.

Viscosity of cream was done by using Brooke field viscometer at the temperature of 25°C using spindle no. 63 at 5rpm. ¹⁶

The prepared cream was transferred in a suitable wide mouth container. Set asidefor storage, the oil phase and aqueous phase separation were visualizing after 24h. ^[17

RESULTS

Table 3: Evaluation of Polyherbal Cream

DISCUSSION

The present research mainly focused on the formulation and evaluation of polyherbal cream using various evaluation parameters.This cream formulation was o/w type of emulsion; hence this formulation was easily washed with normal water after application. The prepared formulation had a good spreadability. Viscosity and pH of the cream was in range. The polyherbal cream was non-greasy in nature and easily removable after application. The formulation was non-irritant and is not harmful to the skin. The prepared cream showed no phase separation while storage.

CONCLUSION

The incorporated herbs such as the dried leaves of Azadirachta indica and dried leaves of Nyctanthes arbor-tristis have antibacterial, anti-inflammatory analgesic activity. Formulation of polyherbal cream was done by Fusion method and further evaluated by various evaluation parameters such as physical properties, pH, Spreadability, Wash ability, non-irritancy test, viscosity and phase separation of cream gave quite good results. The present experimental study showed that it is possible to develop and evaluate polyherbal cream with herbal extract for anti-microbial activity.

Acknowledgement

The authors are thankful to SJVPM’s Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research for providing the facilities required for carrying out this research work.

Conflict of Interest

We, authors declare that we have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper.

REFERENCES

1. Saraf S, Kaur CD. Phytoconstituents as photoprotective novel cosmetic formulations. Pharmacogn Rev. 2010; 4:1-11. https://doi.org/10.4103/0973-7847.65319

2. Akhtar N, Khan BA, Mahmood T, Parveen R, Qayum M, Anwar M, et al. Formulation and evaluation of antisebum secretion effects of sea buckthorn w/o emulsion. J Pharm Bioallied Sci. 2010; 2:13-7. https://doi.org/10.4103/0975-7406.62698

3. Ashawat MS, Banchhor M, Saraf S. Herbal cosmetics: Trends in skin care formulation. Pharmacogn Rev. 2009; 3:82-9.

4. Ashwini S Dhase, Somishwar S Khadbadi, Shweta S Saboo. Formulation and evaluation of vanishing herbal cream of crude drugs. Am J Ethnomed 2014; 1:313-8.

5. Jadhav Santosh, Patil Manojkumar. A review on: nyctanthes arbor-tristis linn. Rejuvenating herbs. Int J Res Pharm Sci 2016; 1:54-62.

6. Timur Tashan S., Kafkasli A. The effect of bitter almond oil and massaging on striae gravidarum in primiparaous women. J. Clin. Nurs. 2012; 21:1570-1576. doi: 10.1111/j.1365-2702.2012.04087. x.

7. Tadimalla TR. 23 benefits of chickpea flour/gram flour/besan for skin, hair & health, Available from http://www.stylecraze.com/articles/ benefits-of-besangram-flour-for-skin-and-hair/gref. cited 19 June 2017

8. Kumar, D., Rajora, G., Parkash, O., Himanshu, Antil, M. & Kumar, V. Herbal cosmetics- a review. International Journal of Advanced Scientific Research, 2016a ; 1(4):36-41

9. Rousseaux, C.G., & Schachter, H. Regulatory issues concerning the safety, efficacy, and quality of herbal remedies. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 2003; 68(6):505-510. https://doi.org/10.1002/bdrb.10053

10. Amol K. D. and Ravindra S. J. et al. A review on Nyctanthes Arbor-tristis Leaves: A potential medicinal herb. WJPMR, 2022; 8(4):128-132.

11. Chandrasekar R., Sivagami B., Formulation and Evaulvation of a Poly Skin Care Cream Containing Neem and Tulsi. Research Journal of Topical and Cosmetics Sciences, 2018; 9(1):25. https://doi.org/10.5958/2321-5844.2018.00006.7

12. Prashant C., Mallinath K., et al. Formulation and Evaulvation of Polyherbal Cream.International Journal of Current Pharmaceutical Research, 2020; 12(4).

13. Ruhil P, Kumar V, Minochi N. Formulation and evaluation of herbal cream used in the treatment of arthritis research. Indian J Res 2018; 7:356-7.

14. SK Uddandu Saheb, Aduri Prakash Reddy, K Rajitha, B Sravani, B Vanitha. Formulation and evaluation of cream from naturally containing plant extract. World J Pharm Sci 2018; 7:851-61

15. Shukla R, Kashaw V. Development, characterization and evaluation of poly-herbal ointment and gel formulationcontaining neriumindicum mill, artocarpusheterophyllus lam, murraya koenigii linn, punicagranatum linn. J Drug Delivery Ther 2019; 9:64-9. https://doi.org/10.22270/jddt.v9i2.2381

16. Kumar, A., Naguib, Y.W., Shi, Y.C., & Cui, Z. A method to improve the efficacy of topical eflornithine hydrochloride Cream. Drug Delivery, 2016b; 23(5):1495-501.

17. Miller, J.N., & Rice-Evans, R.C. Factors Influencing the antioxidant activity determined by the ABTS + radical cation assay. Free Radical Research, 1997; 26(3):195-199. https://doi.org/10.3109/10715769709097799