A STUDY ON EVALUATION OF THE EFFICACY OF LAMOTRIGINE AS ADD-ON TREATMENT IN RESISTANT TYPE OF PRIMARILY GENERALIZED TONIC-CLONIC EPILEPSY IN BURDWAN MEDICAL COLLEGE, WEST BENGAL, INDIA

  • Debasis Bandyopadhyay ASSOCIATE PROFESSOR, DEPARTMENT OF PHARMACOLOGY, BURDWAN MEDICAL COLLEGE, WEST BENGAL, INDIA. BURDWAN MEDICAL COLLEGE, WEST BENGAL, INDIA. PIN NO. 713104.

Abstract

Background: Treatment of resistant type of Primarily Generalized Tonic-Clonic (PGTC) Epilepsy is a difficult area. In different parts of the world lots of studies conducted on this area with varying results. In this perspective, there was need of this study, especially in this part of the country, Burdwan Medical College, West Bengal, India, where previously there was no such study.

Objective: The objective of my study was to evaluate the efficacy of Lamotrigine as Add-On Treatment in Primarily Generalized Tonic-Clonic Epilepsy.

Materials and Methods: 46 resistant type of Primarily Generalized Tonic-Clonic Epileptic patients were randomly recruited from the Out Patient Department (OPD), Burdwan Medical College& Hospital, West Bengal. The patients were taking either Valproic acid or Carbamazepine or combination of Valproic acid & Carbamazepine. All were placed on oral Lamotrigine in addition to their exiting antiepileptic drugs. Efficacy was measured subsequently by efficacy measuring scale.

Results: After add-on Lamotrigine 50% responder rate was 39.129%. 5 patients (10.869%) rendered seizure free. The reduction of mean seizure frequency was 47.129% and response ratio was -0.32 ± 0.249 (mean ± SD). Add-on lamotrigine cause significant reduction (p < 0.05) of seizure frequency from the baseline value and desirable effects were seen irrespective of patients whether taking valproic acid or carbamazepine or combination of valproic acid& carbamazepine. CONCLUSION: Add-on lamotrigine was efficacious in resistant type of Primarily Generalized Tonic- Clonic Epilepsy, in this tertiary care teaching hospital.

Key Words: Epilepsy, Primarily, Generalized, Tonic-Clonic, Resistant

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Bandyopadhyay D. A STUDY ON EVALUATION OF THE EFFICACY OF LAMOTRIGINE AS ADD-ON TREATMENT IN RESISTANT TYPE OF PRIMARILY GENERALIZED TONIC-CLONIC EPILEPSY IN BURDWAN MEDICAL COLLEGE, WEST BENGAL, INDIA. JDDT [Internet]. 31Jul.2013 [cited 27Jan.2022];3(1). Available from: http://www.jddtonline.info/index.php/jddt/article/view/597