ANTIULCER ACTIVITY OF PONGAMIA PINNATA IN RATS
Pongamia pinnata (Linn) belonging to the family Fabaceae (Papilionaceae) commonly known as Karanj. It is a small evergreen tree, which is widely distributed in India, Bangladesh, China, and Australia. The anti-ulcer activity of methanolic extract of Pongamia pinnata (L) (MEPP) was investigated in HCl/ethanol and aspirin induced ulcer models in wistar rats. In both models the common parameter determined was ulcer index. MEPP at doses of 50 and 500 mg/kg p.o produced significant inhibition of the gastric lesions induced by aspirin induced ulcer & HCL/ethanol induced gastric ulcer. The extract (50 mg/kg & 500 mg/kg) showed significant (P<0.05) reduction in ulcer index as compared to control. This present study indicates that Pongamia pinnata (L.) extract have potential anti ulcer activity in the both models. These results may further suggest that methanolic extract was found to possess antiulcerogenic as well as ulcer healing properties.
Key words: - Pongamia pinnata (L.), HCl/ethanol induced ulcer, Aspirin induced ulcer, Ulcer index.
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