Tapentadol: Use and Abuse

Tapentadol – Use and Abuse

  • CV Juvin Thomas Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India
  • R Sambathkumar Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India https://orcid.org/0000-0003-1454-9582
  • N Venkateswaramurthy Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India https://orcid.org/0000-0002-8623-7898


Tapentadol is a synthetic opioid analgesic that has been on the market in India since 2011. According to international studies, there is a low danger of abuse and diversion. Prescription opioid pain reliever abuse remains a major public health concern. Tapentadol, a prescription painkiller, differs from opioids such as oxycodone and morphine in that it has two modes of action: opioid receptor agonism and norepinephrine reuptake inhibition. Tapentadol has been on the market in India for eight and a half years. Our center was the topic of a single peer-reviewed research in 2017 that detailed two instances of abuse. Tapentadol is less likely to be diverted, abused, addicted, overdosed, or sold on the street than other prescribed opioids. This article reviews uses, pharmacological properties and abuse of tapentadol as it is the most serious issues like addiction, seeking behavior, withdrawal, and physical dependency .The main challenge with tapentadol use is controlling the ratio of MOR agonist to NRI. Finally, tapentadol provides both nociceptive and neuropathic pain relief, but there are concerns about abuse and reliance.

Keywords: Tapentadol, Abuse, Opioid, Addiction.

Keywords: Tapentadol, Abuse, Opioid, Addiction


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Author Biographies

CV Juvin Thomas, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

R Sambathkumar, Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

N Venkateswaramurthy, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India


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Juvin Thomas C, Sambathkumar R, Venkateswaramurthy N. Tapentadol: Use and Abuse. JDDT [Internet]. 15Nov.2021 [cited 17Jan.2022];11(6):238-43. Available from: http://www.jddtonline.info/index.php/jddt/article/view/5139