Evaluation of Efficacy of Cucumis melo in Gentamycin and CPD Induced Urolithiasis on Rats

  • Dhaval M Patel SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India
  • Advaita B Patel SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India
  • Bhumi R Patel SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India
  • Deepa R Patel Kalol Institute of Pharmacy, Kalol, Gandhinagar, Gujarat, India
  • Nishith K Patel Arihant School of Pharmacy and Bio-Research Institute, Gandhinagar, Gujarat, India

Abstract

Evaluation of the efficacy of methanolic extract of Cucumis melo in urolithiasis induced by gentamycin and calculi producing diet on Wistar rats. Gentamycin (40 mg/kg, subcutaneously) and calculi-producing diet (CPD) was fed to induce urolithiasis on Wistar rats. The effect of oral administration of methanolic extract of Cucumis melo seed on calcium oxalate urolithiasis has been studied and is compared with the effect of oral administration of Cystone as standard on Wistar rats. Gentamycin and CPD feeding resulted in hyperoxaluria and calcium oxalate deposition as well as increased renal excretion of calcium and oxalate. Supplementation with methanolic extract of Cucumis melo seed reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the seed of Cucumis melo is endowed with antiurolithiatic activity.


Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

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Author Biographies

Dhaval M Patel, SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India

SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India

Advaita B Patel, SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India

SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India

Bhumi R Patel, SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India

SAL Institute of Pharmacy, Opp-Science city, Ahmedabad-380060, Gujarat, India

Deepa R Patel, Kalol Institute of Pharmacy, Kalol, Gandhinagar, Gujarat, India

Kalol Institute of Pharmacy, Kalol, Gandhinagar, Gujarat, India

Nishith K Patel, Arihant School of Pharmacy and Bio-Research Institute, Gandhinagar, Gujarat, India

Arihant School of Pharmacy and Bio-Research Institute, Gandhinagar, Gujarat, India

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Patel DM, Patel AB, Patel BR, Patel DR, Patel NK. Evaluation of Efficacy of Cucumis melo in Gentamycin and CPD Induced Urolithiasis on Rats. JDDT [Internet]. 26Feb.2021 [cited 18Apr.2021];11(1-s):113-6. Available from: http://www.jddtonline.info/index.php/jddt/article/view/4568