A Review on Gastro-Retentive Floating Microspheres
The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than gastric juice and remain floating on gastric juice for a long period of time without impacting the gastric-emptying rate and increasing bioavailability. Gastro-retentive microspheres are particularly suitable for the continuous or late release of oral formulations with blending versatility to achieve various release patterns, low dose risk as a reproducible and short gastric retention time. The aim of this review is to address literature on the floating device, techniques, selection of suitable or inappropriate drug candidates for GRDDS, low density polymers used to swim over gastric fluid, processes, and floating microsphere assessment and application.
Keywords: GRDDS, Floating system, Approaches, Polymer, Mechanism, Methods
2. Mirmeera GN, Kannan K, Madhukar. A Overview on Floating drug delivery system. International Journal of Applied Pharmaceutics. 2018; 10(6):66-70.
3. Lalit K, Abhishek S. Gastro Retentive Floating Microsphere: A Review. Journal of Pharmaceutical Sciences & Bioscientific Research. 2019; 9(2):142-148.
4. Shinde TS, Barathe AN. A Review on Floating Microsphere. Journal of Pharmaceutical and Biological Sciences Archive.2019; 7(3):87-92.
5. Radha R, Manish K, Narendra Y, Shailendra B, Anuj M, Beena K , Sangeeta D, Anil K. Recent Advances In the Development of Floating Microspheres for the Treatment of Gastric Ulcers. International Journal of Advanced Sciences and Technology.2020; 29(5):3613-3627
6. Sonia N, Johan W, I, Kumaran J, Aprana P, Jaghatha T.A. Review on Floating drug delivery system. Word Journal of Pharmaceutical and Medical Research.2018; 4(5):275-281.
7. Satyajit P, Priyanka K, R Varaprasad, Snigdha P. Gatroretentive Microsphere: An Innovative Approach for prolonging Gastric Residence. International Journal of Drug Delivery Technology.2019; 9(1):1-9.
8. Swapnil M, Kaustubh G, Onkar D, Prasad K. Gatroretentive Drug Delivery System. Journal of Drug Delivery & Therapeutics. 2018; 8(4):24-35. DOI https://doi.org/10.22270/jddt.v8i4.1788
9. Shailaja P, Ashutosh B, Preeti k. A review on Gastroretentive drug delivery System. International Journal of Research and Development in Pharmacy and Life Sciences. 2016; 5:2178-2187.
10. Amit KN, Ruma M, Biswarup D. Gastroretentive Drug Delivery System: A review. Asian Journal of Pharmaceutical and Clinical Research. 2010; 3(1):2-10.
11. Shaikh S, Molvi KI, Sayyed N. Various perspectives of Gastroretentive drug delivery System: A Review. American Journal of Advanced Drug Delivery. 2013; 1:443-451.
12. Ankur RS and Afroz K, Gastroretentive drug delivery system: An Approach to Enhance Gastric Retention for Prolonged Drug Release. International Journal of Pharmaceutical Sciences and Research. 2014; 5(4):1095-1106.
13. Nilesh K, Mukta K, Jyoti R, Shashikant ND. Formulation & Evaluation of Gatroretentive Floating Microsphere: A systematic review. International Journal of Pharmaceutical Sciences & Research. 2020; 11(1):1000-13.
14. Gholap SB, Banarjee SK, Gaikwad DD, Jadhav SL, Thorat RM. Hallow Microsphere. International Journal of Pharmaceutical Sciences Review and Research. 2010; 1(1):74-79.
15. Shaikh SZ, Shahid M. Floating tablet & its polymer. Journal of Drug Delivery & Therapeutics. 2018; 8(5-s):16-24. DOI https://doi.org/10.22270/jddt.v8i5-s.1928
16. Gayathridevi MJ. Adlin Jino Nesalin and T. Tamizh Mani. Floating Microsphere: A Review. International Journal of Research in Pharmacy and Chemistry. 2016; 6(3):501-510.
17. Deshmukh M.T, Mohite S.K. Mucoadhesive Microsphere as a Drug Delivery System: A Review. Journal of Current Pharmaceutical Research. 2015; 5(3):1505-1512.
18. Satinder K, Deep B, Ramandeep S, Ujjwal N. Magnetic Microsphere as Magical Novel Drug Delivery System: A review. Journal of Acute Disease. 2013; 2(1):1-12.
19. Iyan S, Sriwidodo, Retno, Wahyuningrum, Norsca Aliza P. A review: Floating drug delivery system as tool to Improve dissolution rate in gastric. International Journal of Applied Pharmaceutics. 2020; 12(4):51-54.
20. Manisha M, Saudagar R B. Microsphere A review. Journal of Drug Delivery and Therapeutics. 2019; 9(3-s):854-856. DOI https://doi.org/10.22270/jddt.v9i3-s.2826
21. Tarun V and Jyoti G. Pharmaceutical Application of Microsphere: an approach for the treatment of various disease. International Journal of Pharmaceutical Sciences & Research. 2017; 8(8):3252-3260.
22. Swati M. Aute, Santosh A. Payghan, John I. D’Souza, Smita Navhkar, Dhanshree Lad, Umesh Jirole. Novel Approach in Gastro Retentive Drug Delivery System: Floating microsphere. International Journal of Pharmacy and Biological Sciences Archive. 2014; 2(5):09-22.
23. Anamika S, Kalpesh G, Virendra S, Rajneesh KS, and Ashok D Floating Microspheres as Drug Delivery System. American Journal of Pharmacy and Pharmaceutical Sciences. 2014; 1(2):27-36.
24. Ishwaryal M, Ramu S, Saravana K. Floating Microspheres: A Promising Drug Delivery. International Journal of Pharmacy & Pharmaceutical Research. 2017; 11(1):375-388.
25. Koteswararao SR, Srinivas L. A Review on Multi-Particulate Floating Microspheres Drug Delivery System with Solvent Evaporation Approach. Int J of Pharm Res and Health Sci. 2018; 6(3):2570-78.
26. Rakesh P, Neeta, Shiv B. Vipin K and Kanchan K. Floating Microsphere: An Innovative Approaches for Gastric retention: Der Pharmacia Lettere. 2010; 2(4):461-475.
27. Kapil K, Rai AK. Floating Microsphere: An Innovative Approach for Gastro retention. J of Pharm Res. 2012; 5(2):883-886.
28. Gandhi S, Dadi S, Ramesh J, Kalyani V, Nagamma I. Floating Microspheres: A Prevailing Trend in the Development of Gastroretentive Drug Delivery System. Asian J of Pharm. 2018; 12(4):235-241.
29. Vishakha RJ, Swapnil RP, Tushar DF. A Review on: Floating Microsphere. American Journal of Pharmaceutical Technique Research. 2020; 10 (2):231-258.
30. Aundumber D, Ritesh SB, Manoj K P. Floating Microsphere: A Novel Approach in Drug Delivery System. GCC J of Sciences & Technology. 2015; 1(5):134-153.
31. Kumar R, Kumar P, Chandra S, Formulation and Evaluation of Multiple Unit Floating Beads of Antiulcer Drug. Asian Journal of Pharmacy. 2018; 12(2):680-689.
32. Sahoo SK, Mallick AA, Barik. Formulation and in-vitro evaluation of eudragit® Microspheres of stavudine. Tropical Journal of Pharmaceutical Sciences. 2005; 4:369-75.
33. Miranda FC, Kamanth KK, Shabarya AR. Development of gastro retentive floating microsphere of roxatidine acetate HCL by emulsion solvent diffusion technique. International Journal of Diabetes in Developing Countries. 2019; 9(4)531-537.
34. Swetha K, Madhavi HS, Vasudha B. Formulation and Evaluation of Gastro Retentive Floating Microsphere of Nimodipine. Asian Journal of Pharmacy. 2016; 10:628-635.
35. Srivatava, AK, Ridhurkar DN, Saurabh W. Floating Microspheres of Cimetidine: Formulation, Characterization and In Vitro evaluation. Acta Pharmaceutical. 2005; 55:277–285.
36. Prakash G, Shashikanth R. Development and in vitro characterization of esomeprazole floating gastro retentive Microsphere. Journal of applied Pharmaceutical Sciences. 2013; 3:71-77.
37. Sanjay KM, Gupta MK. Characterization and Evaluation of Nizatidine Floating Microsphere based drug delivery system for antiulcer activity. International Journal of Pharmaceutical Sciences & Research.2019; 10:4557-4567.
38. Prinderre, P, Sauzet, C, Fuxen, C. Advances in gastro retentive drug‐delivery systems. Expert Opin. Drug Delivery.2011; 8: 1189–1203.
39. Thapa, P, Jeong, S. Effects of Formulation and Process Variables on Gastroretentive Floating Tablets with A High‐Dose Soluble Drug and Experimental Design Approach. Pharmaceutics.2018; 10:1–25.
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