Acute toxicity and central and peripheral analgesic activity of flowers and leaves essential oils of Asteriscus graveolens from South-West Algeria
Abstract
The objective of this study is the evaluation of the central and peripheral analgesic activity of the leaves and flowers Essential Oils (EOs) of Asteriscus graveolens as well as their acute toxicity. The pharmacological tests were performed using an animal model. Acute toxicity was determined by Lorke's method. Central analgesic activity was evaluated by the hot plate test, and peripheral analgesic activity was conducted by the writhing test. The results showed that the EOs of A. graveolens from both organs are weakly toxic. For the central analgesic activity, the results revealed that leaf EO have a remarkable antinociceptive effect compared to flowers EO with a maximum latency time of the animals on the hot plate on the order of 22.5 seconds. Finally, the peripheral analgesic activity revealed a maximum inhibition of abdominal writhing of 99% for flowers EO and 96% for leaves EO.
Keywords: Asteriscus graveolens, analgesic activity, toxicity.
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2- Said MEA, Vanloot P, Bombarda I, et al,” Analysis of the major chiral compounds of Artemisia herba-alba essential oils (EOs) using reconstructed vibrational circular dichroism (VCD) spectra: En route to a VCD chiral signature of Eos” Anal Chim Acta, 2016; 903:121-130.
3-Said MEA, Militello M, Saia S, et al, ”Artemisia arborescens Essential Oil Composition, Enantiomeric Distribution, and Antimicrobial Activity from Different Wild Populations from the Mediterranean Area”Chem Biodivers,2016; 13(8):1095-102.
4-Cheriti A, Saad A, Belboukhari N, et al. “ The essential oil composition of Bubonium graveolens (Forssk) Maire from the Algerian Sahara” Flavour Fragr, 2007; J 22:286-286.
5-Cristofari G, Znini M, Majidi L, et al, “Chemical diversity of essential oils from Asteriscus graveolens (Forssk) less.: identification of cis-8-Acetyloxychrysanthenyl acetate as a new natural component” Chem Biodivers, 2012; 9:727-738.
6-Said MEA, Bombarda I, Naubron JV, et al, “ Isolation of the major chiral compounds from Bubonium graveolens essential oil by HPLC and absolute configuration determination by VCD” Chirality, 2017; 29(2):70-79.
7-Jakupovic J, Lehmann L, Bohlman F, et al, “Nerolidol derivatives from Asteriscus sericeus”Phytochemistry, 1987; 26:2854-2855.
8-Chaib F, Allali H, Bennaceur M, et al, “ Chemical Composition and Activity of Essential Oils from the Aerial Parts of Asteriscus graveolens (Forssk) Less.and Pulicaria incisa (Lam) DC.: Two Asteraceae Herbs Growing Wild in the Hoggar” Chem.Biodiversity, 2017; 14:e1700092.
9-Al-Rimawi F, Alakhras F, Al-Zereini W, et al, “ HPLC Analysis of Chemical Composition of Selected Jordanian Medicinal Plants and their Bioactive Properties” Oriental Journal of Chemistry, 2018; 34(5):2397-2403.
10-Berbaoui, Cheriti et Ould El Hadj-Khelil, “Antibacterial Effect of Some Asteraceae of Southern Algeria on Nosocomial Strains of the Genus Staphylococcus” Natural Products Chemistry & Research, 2018 6(1).
11-Alilou H, Akssira M, et al, " Isolement, Identification et activite antifongique de deux sesquiterpenes d’Asteriscus graveolens Subsp.Odorus(Schousb.) Greuter" European Scientific Journal, 2016; 12(33).
12-Znini M, Cristofari G, Majidi L, et al, "Antifungal Activity of Essential Oil from Asteriscus graveolens against Postharvest Phytopathogenic Fungi in Apples"Natural product communications, 2011; 6(11):1763-1768.
13-Znini M, Cristofari G, Majidi L, et al, "Green Approach to Corrosion Inhibition of Mild Steel by Essential Oil Leaves of Asteriscus Graveolens (Forssk.) in Sulphuric Acid Medium" Int J Electrochem Sci, 2012; 3959 – 3981.
14-Haddouchi F, Chaouche TM, Halla N, "Screening phytochimique, activités antioxydantes et pouvoir hémolytique de quatre plantes sahariennes d’Algérie"Phytothérapie, 2016.
15-Aouissi H, Gourine N, Wang H, et al, "Chemical composition, antioxidative, antimicrobial and anti‑cancer activities of Asteriscus graveolens (Forssk) essential oil" Oriental Pharmacy and Experimental Medicine, 2018
16-Ramdane F, Essid R, Mkadmini K, et al, "Phytochemical composition and biological activities of Asteriscus graveolens (Forssk) extracts" Process Biochemistry, 2017.
17- Vogel HG, Hock FJ, Maas J, et al. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, 1er ed. Berlin; New York: Springer;2006.
18- Turner PV, Brabb T, Pekow C, et al. Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider. J Am Assoc Lab Anim Sci JAALAS; 2011; 50:600–613.
19- Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol; 1983. 54:275–287.
20-Eddy NB, Leimbach D, "Synthetic analgesics II. Dithienylbutenyl- and dithienylbutylamines" J Pharmacol Exp Ther,1953; 107: 385-393.
21- Muhammad N, Saeed M, Khan H, "Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant" BMC Complement. Altern. Med, 2012; 12, 59.
22-Hodge HC, Sterner JH. Tabulation of Toxicity Classes. Am.Ind.Hyg.Assoc.Q; 1949; 10:93-96.
https://doi.org/10.1080/00968204909344159
23-Cohen Y, Jacquot C, Valette G. Pharmacologie.France: Elsevier Masson, Issy-les- Moulineaux ;2008.
24-Ramdane F, Hadj Mahammed M, Didi Ould Hadj M, et al, "Ethnobotanical study of some medicinal plants from Hoggar, Algeria"Medicinal Plants Research, 2015; 9(30):820-827.
25-Quezel P, et Santa C. Nouvelle flore de l’Algérie et des régions désertiques méridionales.Paris :CNRS. 1962-1963; 2:1170.
26-Frederico AV, Higor FL, Elson AC, et al, "Evaluation of the antinociceptive and anti-inflammatory effects of the acetone extract from Anacardium occidentale L" Brazil J Pharmaceut Sci, 2009; 45:437-42.
27-Wantana R, Tassanee N, Subhadhirasakul S, "Antinociceptive, antipyretic, and anti-inflammatory activities of Putranjiva roxburghii Wall. Leaf extract in experimental animals" J Nat Med, 2009; 63:290-6.
28-Gorzalczany S, Marrassini C, Mino J, et al, "Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circu-laris" J Ethnopharmacol, 2011; 134:733-8.
29-Prashant RV, Amit AJ, Vivekanand AC, Alpana JA, "Antinociceptive activity of alcoholic extract of Hemidesmus indicus R. Br. In mice" J Ethnopharmacol, 2005; 102 :298-301.
30- Ghourri M, Zidane L, El Yacoubi H, Rochdi A, Fadli, Douira A, "Etude floristique et ethnobotanique des plantes médicinales de la ville d’El Ouatia (Maroc Saharien)" Journal of Forestry Faculty, 2012; 12(2):218-235.
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