Antihyperglycemic Effect of Methanolic Extract of Aphanamixis polystachya Leaves on Streptozotocin-Induced Diabetic Rats
This study aimed to investigate the antidiabetic effect of methanolic extract of Aphanamixis polystachya leaves in streptozotocin (STZ) induced diabetic rats. Wistar rats in each were divided into six groups and these animals were used for the study. In our study methanolic extract of Aphanamixis polystachya leaves was screened for antidiabetic activity in streptozotocin (STZ)-induced diabetic rats. The anti-diabetic activity was assessed using blood glucose level, body weight and various biochemical parameters like serum total cholesterol level (TC), triglyceride (TG) level, high-density lipoproteins (HDL), total protein (TP), serum alanine transaminase (SGPT) and aspartate aminotransferase (SGOT), respectively. The methanolic extract of Aphanamixis polystachya leaves exhibited an antidiabetic effect by significantly decreased the level of blood glucose, body weight, TC, TG, TP and increase HDL. The results of the study demonstrated that the treatment with methanolic extract of Aphanamixis polystachya leaves signiﬁcantly (P<0.05) and dose-dependently prevented STZ-induced diabetic rats. The antioxidant property of plant phenolic and flavonoid contents present in methanolic extract of Aphanamixis polystachya leaves might be responsible for the antidiabetic activity.
Keywords: Aphanamixis polystachya leaves; diabetes; streptozotocin
2. Davis S. Insulin, oral hypoglycemic agents and the pharmacology of the endocrine pancreas. In: Brunton L, Lazo J, Parker K. (eds.) Goodman and Gilman’s the pharmacological basis of therapeutics.11th ed. New York: McGraw Hill Publishing; 2006, p. 1613-1646.
3. Mukherjee P, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol 2006; 106(1):1-28.
4. Pandita R, Phadke A, Jagtap A. Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats. J Ethnopharmacol 2010; 128(2):462-466.
5. Patel P, Harde P, Pillai J, Darji N, Patel B. Antidiabetic herbal drugs a review. Pharmacophore. 2012; 3(1):18–29.4.
6. Gandhi GR, Sasikumar P. Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2012; 2:281-86.
7. Wang J, Ryu HK. The effects of Momordica charantia on obesity and lipid profiles of mice fed a high-fat diet. Nutrition research and practice. 2015; 9(5):489-495.
8. Andallu B, Kumar AV, Varadacharyulu NC. Lipid abnormalities in streptozotocin-diabetes: amelioration by Morus indica L. cv Suguna leaves. International journal of diabetes in developing countries. 2009 Jul; 29(3):123.
9. Komeili G, Hashemi M, Bameri-Niafar M. Evaluation of antidiabetic and antihyperlipidemic effects of peganum harmala seeds in diabetic rats. Cholesterol. 2016; 2016.
10. Briones ER, Mao SJT, Palumbo PJ, “Analysis of plasma lipids and apolipoproteins in insulin-dependent and noninsulin-dependent diabetics,” Metabolism, 1984; 33(1):2–49.
11. Kondeti VK, Badri KR, Maddirala DR, Thur SKM, Fatima SS, Kasetti RB, et al. Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin induced diabetic rats. Food Chem Toxicol. 2010; 48:1281–1287.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).