Development of Transdermal Patches for the Delivery of Chlorpheniramine in Infants using Hypromellose and Cassava Starch Composite Polymers

  • Chukwuma O. Agubata Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka https://orcid.org/0000-0002-7797-0975
  • Blessing B. Nta Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka
  • Godswill C. Onunkwo Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka
  • Parker E. Joshua Department of Biochemistry, University of Nigeria Nsukka
  • Sabinus I. Ofoefule Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka
  • Remigius I. Onoja Department of Veterinary Pathology and Microbiology, University of Nigeria Nsukka

Abstract

Background: Chlorpheniramine is an antihistamine that is used in the treatment of rhinitis and other allergies. Objectives: The objectives of this research was to develop and evaluate transdermal patches for improved delivery of chlorpheniramine in infants using hypromellose and cassava starch composite polymers. Methods: Chlorpheniramine transdermal patches were formulated by solvent casting method using varying amounts of hypromellose (hydroxypropyl methylcellulose), cassava starch and polyethylene glycol 4000. The formulated transdermal patches were characterized by Fourier Transform Infra-red Spectroscopy (FT-IR), folding endurance, elongation breaking test, percentage moisture uptake/loss and ex vivo permeation studies. Results: The spectra showed no chemical interaction between the ingredients. The transdermal patches showed elastic qualities and high folding endurance. Patches with consistently high moisture uptake (around 40%) were observed to contain high concentration of cassava starch while those with higher amounts of HPMC lost more water (around 35%). The ex vivo study showed efficient permeation and flux for the target purpose. Conclusion: Transdermal patches may be used to deliver low dose chlorpheniramine drug through the skin possibly soft and thin infant skin.


Keywords: Transdermal; permeation; flux; allergy; chlorpheniramine

Keywords: Transdermal, permeation, flux, allergy, chlorpheniramine

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Author Biographies

Chukwuma O. Agubata, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Blessing B. Nta, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Godswill C. Onunkwo, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Parker E. Joshua, Department of Biochemistry, University of Nigeria Nsukka

Department of Biochemistry, University of Nigeria Nsukka

Sabinus I. Ofoefule, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka

Remigius I. Onoja, Department of Veterinary Pathology and Microbiology, University of Nigeria Nsukka

Department of Veterinary Pathology and Microbiology, University of Nigeria Nsukka

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Agubata CO, Nta BB, Onunkwo GC, Joshua PE, Ofoefule SI, Onoja RI. Development of Transdermal Patches for the Delivery of Chlorpheniramine in Infants using Hypromellose and Cassava Starch Composite Polymers. JDDT [Internet]. 15Jul.2020 [cited 30Sep.2020];10(4):125-32. Available from: http://www.jddtonline.info/index.php/jddt/article/view/4163