Development and Evaluation of Gastro-retentive Floating Tablet of Rilpivirine Hydrochloride for the Treatment of HIV

  • Dipali Trivedi Smriti College of Pharmaceutical Education, Indore (M.P.), India
  • Arti Majumdar Smriti College of Pharmaceutical Education, Indore (M.P.), India
  • Neelesh Malviya Smriti College of Pharmaceutical Education, Indore (M.P.), India

Abstract

Besides enormous improvements in drug delivery, oral route has been highly and effectively utilized route of administration. Floating drug delivery that is also known to be low density system is advancement in the class of gastro-retentive drug delivery system. In the present research work, floating drug delivery of Rilpivirine hydrochloride was developed by overcoming various limitations and troubles associated with the drug including poor absorption in intestinal pH and degradation when comes in contact with higher pH environment. [2] Prepared formulations were evaluated for various parameters like friability, hardness, thickness, drug content analysis, floating properties and in-vitro drug release study. Based on the evaluation, concluded that floating drug delivery system is a non-toxic as well as cost-effective technique for the rationale of enhancing bioavailability and absorption of poorly water soluble drugs. The improvement in gastric residence time is a clear sign. It can be able to use in the future for more acidic soluble drugs to enhance solubility and absorption.


Keywords: Floating drug delivery, gastric residence time, Rilpivirine, effervescent, NNRTI.

Keywords: Floating drug delivery, gastric residence time, Rilpivirine, effervescent, NNRTI

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Author Biographies

Dipali Trivedi, Smriti College of Pharmaceutical Education, Indore (M.P.), India

Smriti College of Pharmaceutical Education, Indore (M.P.), India

Arti Majumdar, Smriti College of Pharmaceutical Education, Indore (M.P.), India

Smriti College of Pharmaceutical Education, Indore (M.P.), India

Neelesh Malviya, Smriti College of Pharmaceutical Education, Indore (M.P.), India

Smriti College of Pharmaceutical Education, Indore (M.P.), India

References

1. Reeves J, Doms R. Human Immuno-deficiency Virus. Journal of General Virology. 2002; 83(6):1253-1265.
2. Sharma M, Louis D. Rilpivirine: a new non-nucleoside reverse transcriptase inhibitor. Journal of Antimicrobial Chemotherapy. 2012; 68:250-256.
3. Bhatti A, Usman M, Kandi V. Current scenario of HIV/AIDS, treatment options, and major challenges with compliance to antiretroviral therapy. Cureus Publishing. 2016; 8(3):1-12.
4. Baumgartner S, Kristl J, Vrecer F. Optimization of floating matrix tablet and evaluation of their gastric residence time. International Journal of Pharmaceutics. 1999; 195(2000):125-135.
5. Ansel CH, Loyd V. Pharmaceutical dosage form and drug delivery system. International Journal of Pharmaceutical compounding. 9th edition, 2011.
6. Vyas SP, Khar R. Controlled Drug Delivery concepts and advances. 2nd edition, 2012.
7. Dubey J, Verma N. Floating Drug Delivery System: A Review. International Journal of Pharmaceutical Science and Research. 2013; 4(8):2893-2899.
8. Tripathi J, Thapa P. A review on current state and future perspective on GRDDS. MDPI. 2019; 11(4):6-16.
9. Kommavarapu P, Sunkara M. Preparation and characterization of Rilpivirine solid dispersion with application of enhanced solubility and dissolution rate. Beni-Suef University Journal of Basic and Applied Sciences. , 2015; 4:2-4.
10. Ramesh, K, Micronization and formulation for improvement of rate of dissolution of Rilpivirine. Beni-Suef University Journal of Basic and Applied Sciences. 2015; 1-2.
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1.
Trivedi D, Majumdar A, Malviya N. Development and Evaluation of Gastro-retentive Floating Tablet of Rilpivirine Hydrochloride for the Treatment of HIV. JDDT [Internet]. 15Jun.2020 [cited 29Mar.2024];10(3-s):43-6. Available from: https://www.jddtonline.info/index.php/jddt/article/view/4115