Designing and Synthesis of Flavonoids Derivatives and Screening of their Antimicrobial Activity

  • Mukesh Sharma Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Dharmendra Ahuja Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Anurekha Jain Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Rakesh Goyal Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Abstract

Antimicrobial drugs either kill microbes (microbicidal) or prevent the growth of microbes (microbistatic). The streptococcus mutans is a bacteria that found in the human mouth cavity. This bacterial strain produces plaque and acids that break down tooth enamel and cause dental caries. Gram positive cocci, facultatively anaerobic bacteria that forms rod-like chains. the chemical reaction of 2- hydroxyacetophenones with aromatic acylchloride occurs to form 1,3-diketones. This rearrangement reaction proceeds via enolate formation followed by acyl transfer. Then it cyclises into flavone.13 As the same of above scheme can be worked out as 2- Methoxybenzoyl Chloride is prepared by reaction of 2- methoxybenzoic acid  with  Thionyl chloride and DMF. 2-Methoxybenzoyl Chloride then added to mixture of 2- hydroxyacetophenone and pyridine, 2-[(2-Methoxybenzoyl)oxy]acetophenone thus obtained is treated with pyridine and KOH which gives1-(2-Hydroxyphenyl)-3-(2- methoxyphenyl)-propan1,3-dione. The result of study indicated that C5 [1-(2- hydroxyphenyl)-5-phenylpenta-2,4-dien-1-one]; is only inactive against Streptococcus mutans. All 3-hydroxyflavone derivatives exhibited their MIC to be in range of 250-125 µg/ml., 2,3-dihydroflavan-3-ol derivatives exhibited their MIC to be in  range of  1000- 500 µg/ml. The chalcone derivatives exhibited their MIC to be at 250 µg/ml.


Keywords: Streptococcus mutans, flavonoids derivatives, MIC, 2,3-dihydroflavan-3-ol.

Keywords: Streptococcus mutans, flavonoids derivatives,, MIC, 2,3-dihydroflavan-3-ol

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Author Biographies

Mukesh Sharma, Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Dharmendra Ahuja, Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Anurekha Jain, Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Rakesh Goyal, Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

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Sharma M, Ahuja D, Jain A, Goyal R. Designing and Synthesis of Flavonoids Derivatives and Screening of their Antimicrobial Activity. JDDT [Internet]. 30Aug.2019 [cited 29Oct.2020];9(4-A):916-20. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3966