Influence of Cinnamomum camphora ethanolic extract on Biophysical and Biochemical Parameters of Cutaneous Wounds in Rats
The ethanolic extract of Cinnamomum camphora leaves (100mg/kg/day for 16 days) was evaluated for its wound healing activity in rats using excision, incision and dead space wound models. Extract treated animal’s exhibit 95% reduction in wound area when compared to controls which was 84%. The extract treated wounds are found to epithelize faster as compared to controls. The wet and dry granulation tissue weight including Hydroxyproline, elastin and collagen tissue content increased significantly (P< 0.001) when compared with control.
Keywords: Excision wound, Dead space wound, incision, Hydroxyproline, elastin, collegan
2. Goodson WH, et al. Surgery, Gynecology and Obstetrics. 1979: 149; 600.
3. Plants Profile: Cinnamomum camphora". Natural Resources Conservation Service. United States Department of Agriculture. http://plants.usda.gov/java/profile? symbol = CICA. Retrieved 12 April 2010.
4. Liu Z, Kong L, Lu S, Zou Z. Application of a Combined Homogenate and Ultrasonic Cavitation System for the Efficient Extraction of Flavonoids from Cinnamomum camphora Leaves and Evaluation of Their Antioxidant Activity In Vitro. J Anal Methods Chem. 2019; 4892635.
5. Anonymous:http://www.oecd.org/env/ehs/testing/45124234.pdf accessed on 20/8/10
6. Irwin S. Comprehensive observational assessment: Ia. a systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia (Berl.) 1968; 13:222-257.
7. Nayak BS, Anderson M, Periara LMP. Evaluation of wound healing potency of Catharanthus roseus leaf extract in rats. Fitoterapia. Dec.2007; 78(7-8):540-544.
8. Beloz AG, Rusinski JC, Balic MJ, Tipton C, Double incision wound healing bioassay using Hamelia patens from El Salvador. J Ethnopharmacol 2003; 88:169–173.
9. Shivananda BS, Sandiford S, Maxwell A, Evaluation of the Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf. eCAM 2007;1-6. doi:10.1093/ecam/nem127.
10. Reddy KG, Enwemeka SC, A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996; 29:225-229.
11. Neuman RE, Logan MA, The determination of collagen and elastin in tissues. The J Biol Chem 1950; 184:549-556.
12. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341:738–46.
13. Vismer HF, Eicker A. Growth of human pathogenic isolates of Sporothrix schenckii on indigenous and exotic wood species in South Africa. Mycol Res 1994; 98:121-4.
14. Musalmah M, Fairuz AH, Gapor MT, Zurinah W, Ngah W. Effect of vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats. Asia Pacific J Clin Nutr 2002; 11(5): 3448-3451.
15. Lee M, Jiang C, Juan S, Lin R, Hou W. Antioxidant and heme oxygenase-1 (HO-1)-induced effects of selected Taiwanese plants. Fitoterapia 2006; 77:109-15.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).