Pharmacognostical standardization of Albizia lebbeck (L.) BENTH (Fabaceae)

  • Abhishek Suman School of Pharmaceutical Sciences, IFTM University, Moradabad-244102, U.P., India
  • , Mohit School of Pharmaceutical Sciences, IFTM University, Moradabad-244102, U.P., India
  • Mahesh Prasad Director, Faculty of Pharmacy, Kamla Nehru Institue of Management and Technology. Sultanpur-228119, India

Abstract

Albizia lebbeck (L.) BENTH (Fabaceae), commonly known as Sirisha, traditionally used as astringent, to treat boils, cough, pain, swelling and it is also used against diarrhea. In the present investigation, various pharmacognostical standards for A. lebbeck have been established. Collection of plant material was carried out and its morphological, physico-chemical and phytochemical studies including HPTLC of leaf, root and stem of plant were investigated. Microscopically, leaf of A. lebbeck showed presence of anomocytic stomata, arc shaped and cortical parenchyma. The roots of the plant showed cork cambium, secondary phloem, and calcium oxalate crystals and stem exhibited fibres, parenchyma cells, vessels, stomata, palisade cells and trichomes. Phytochemically, the ethyl acetate and methanol extracts of A. lebbeck showed variety of phytochemicals such as alkaloids, glycosides, steroids, flavonoids, saponin, tannin and phenolic compounds. HPTLC profile of ethyl acetate extract revealed up to six phytoconstituents amongst which gallic acid was most prominent. The study concludes that leaves, roots and stem can be differentiated on the basis of macro and microscopic characters, physico-chemical values, HPTLC fingerprint profile and gallic acid detection as marker component. These studies provide referential information for correct identification and standardization of the plant and also be helpful to differentiate A. lebbeck from the closely related other species of Albizia.


Keywords: HPTLC, Gallic acid, Pharmacognostical standardization, Phytochemical analysis.

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References

1 Dr. Duke's. Phytochemical and Ethnobotanical Databases. http://www.ars-grin.gov/duke/. Accessed on: 05.03.18.
2 Anonymous, The Wealth of India: A Dictionary of Indian raw materials & industrial products, Raw Materials, Vol 10 (Sp-W). New Delhi: National Institute of Science Communication and Information Resources (CSIR); 1993. p. 195-200.
3 Envis Centre on Medicinal Plants. Encyclopedia on Indian Medicinal Plants. http://envis.frlht.org/plant_details.php?disp_id=642&parname=0. Accessed on: 05.03.18.
4 The Useful Plants of India. National Institute of Science Communication & Information Resources (CSIR), 5th ed. New Delhi, India; 2006. p. 141.
5 Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Dehra Dun, India: Bishen Singh Mahendra Pal Singh; 1993. p. 549-559.
6 Gupta AK, Sharma Madhu. Reviews on Indian Medicinal Plants. Vol 7 (CI-Co). Medicinal Plant Unit. Indian Council of Medical Research. New Delhi, India; 2008. p. 561-562.
7 Asolkar LV, Kakkar KK, Charke OJ. Glossary of Indian medicinal plants with active principles, Part 1. New Delhi: National Institute of Science Communication And Information Resources (CSIR); 1992. p. 230-231.
8 Bobby N M. D., Wesely, E. G, Johnson, M. 2012; HPTLC studies on the flavonoids of albizia lebbeck benth, International Journal of Advances in Pharmaceutical Research,Research Paper Vol. 3 / Issue. 3 / 830 – 836.
9 Alam P; Ali M. Aeri, Vidhu. 2012; Isolation of a new keto steroid stigmast-4, 20(21), 23-trien-3-one and a new alcohol tricontan-10a-ol from the roots of Albizzia lebbeck Benth,Journal of Natural Product & Plant Resources; Vol. 2 Issue 2, pp 234.
10 Albizia lebbeck bark spectral analysis molecular conformation chemical constituents of plants chemical structure. Phytochemistry. v. 38 (5).
11 Chaddha Varun., Nayak S., Solanki Sarita., 2011; Preliminary Phytochemical Screening On Bark and Pods Of Albizzia Lebbeck Linn, International Journal Of Comprehensive Pharmacy, 11 (06).
12 Uma B., Prabhakar K., Rajendran S., Sarayu L.Y. 2009; Antimicrobial Activity of Albizzia Lebbeck Benth against Infectious Diarrhoea. The Internet Journal of Microbiology Vol 7 Number 1.
13 Steinrut L, Itharat A, Ruangnoo S. Free radical scavenging and lipid peroxidation of Thai medicinal plants used for diabetic treatment. J Med Assoc Thai 2011; 7: 178-82.
14 Aliyu AB, Musa AM, Ibrahim MA, Ibrahim H, Oyewale AO. Preliminary phytochemical screening and antioxidant activity of leave extract of Albizia chevalieri harms (leguminoseae-mimosoideae). Bajopas 2008; 2(1): 149-153.
15 Zheng L, Zheng J, Zhao Y, Wang B, Lijun W, Liang H. Three anti-tumor saponins from Albizia julibrissin. Bioorg Med Chem Lett 2006; 16: 2765–2768.
16 Miyase T, Melek FR, Ghaly NS, Warashina T, El-Kady M, Nabil M. Echinocystic acid 3, 16-O-bisglycosides from Albizia procera. Phytochem 2010; 71(11-12): 375-80.
17 Sabrina K, Odile T, Thierry S, Richard W, Catherine L. Triterpenoid saponin anthranilates from Albizia grandibracteata leaves ingested by primates in Uganda. J of Nat Prod 2005; 68: 897–903.
18 Melek FR, Miyase T, Ghaly NS, Nabil M. Triterpenoid saponins with N-acetyl sugar from the bark of Albizia procera. Phytochem 2007; 68: 1261–1266.
19 Rui L, Shuanggang M, Shishan Y, Yuehu P, Sen Z, Xiaoguang C, Jianjun Z. Cytotoxic oleanane triterpene saponins from Albizia chinensis. J Nat Prod 2009; 72: 632–663.
20 Not OP, Offer AM, Miyamoto T, Paululat T, Mirjolet J, Duchamp O, Pegnyemb D, Dubois ML. Cytotoxic acacic acid glycosides from the roots of Albizia coriaria. J Nat Prod 2009; 72: 1725–1730.
21 Zou, K, ZhaoYY, Zhang RY. A cytotoxic saponin from Albizia julibrissin. Chem Pharm Bull (Tokyo) 2006; 54(8): 1211-2.
22 Lau, CS, Carrier DJ, Beitle RR, Bransby DI, Howard LR, Lay JJ, Liyanage R, Clausen EC. Identification and quantification of glycoside flavonoids in the energy crop Albizia julibrissin. Bioresour Technol 2007; 98: 429-435.
23 Kang TH, Jeong SJ, Kim NY, Higuchi R, Kim YC. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin. J Ethnopharmacol 2000; 71: 321–323.
24 Yadava RN, Tripathi P. Chemical examination and anti-inflammatory action of the extract from the stem of Albizia procera. Res J Chem Environ 2000; 4: 57-60.
25 Correia da Silva AC, Paiva MQ, Costa A. Some aspects of the physiological actions of the alkaloids of Dioscorea dumetorum French and English summ. An Fac Farm Porto 1962; 22: 51-66.
26 Mar W, Tan GT, Cordell GA, Pezzuto JM, Jurcic K, Redl K, Steinke B, Wagner H. Biological activity of novel macrocyclic alkaloids (Budmunchiamines) from Albizia amara detected on the basis of interaction with DNA. J Nat Prod 1991; 54: 1531-1542.
27 Anonymous, World Health Organization, Geneva, Quality control methods for Medicine Plant Materials, 1998.
28 Anonymous, Indian Pharmacopoeia, Vol 2 (P-Z), (Government of India, Ministry of Health and Family Welfare Controller of Publications, New Delhi), 1996.
29 Prathyusha P, Modurpalayam S S, Subramanian S S & Sivakumar R, Pharmacognostical studies on white and red forms of Abrus precatorius Linn, Indian J Nat Prod Res, 1(4) (2010) 476-480.
30 Kataria S, Shrivastava B, Khajuria R K, Suri K A & Sharma P, Pharmacognostic evaluation of Crotalaria burhia Buch.-Ham, Ind J Trad Knowl, 10 (4) (2011) 629-635.
31 Khandelwal K R, Practical Pharmacognosy-Techniques and Experiments, 14th edn, (Nirali Prakashan, Pune), 2005, 153.
32 Ayinde B A, Omogbai Eric K I & Amaechina F C, Pharmacognosy and Hypotensive Evaluation of Ficus Exasperata Vahl (Moraceae) Leaf, Acta Poloniae Pharmaceutica - Drug Res & Nat Drugs, 64(6) (2007) 543-546.
33 Yoshida Tatsushi, Konishi Masako, Horinaka Mano, Yasuda Takashi, Goda Ahmed E & Taniguchi Hiroya, Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis, Biochem & Biophysica Res Comm, 375(1) (2008) 129–133.
34 Leung Henry W C, Lin C J, Hour M J, Yang W H, Wang M Y et al, Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes, Food & Chem Toxicol, 45(10) (2007) 2005–2013.
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Suman A, Mohit , Prasad M. Pharmacognostical standardization of Albizia lebbeck (L.) BENTH (Fabaceae). JDDT [Internet]. 20Dec.2019 [cited 29Nov.2021];9(4-s):1129-37. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3808