Microemulsions: Platform for Improvement of Solubility and Dissolution of Poorly Soluble Drugs

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India
  • Joy Mukherjee GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India

Abstract

This study reviews the impact of microemulsion on the improvement of solubilization and dissolution of lipophilic drug. The drugs which are of poorly soluble and low absorption are considered as ideal candidates for micro emulsions. Microemulsion are thermodynamically stable, having of three components oil phase, surfactants, and co-surfactants. It is having low particle or droplet size range from 5-200 nm and have of low oil/water interfacial tension. These are transparent preparations with no involvement of energy. These preparations improved oral bioavailability and protects the drug from against enzymatic hydrolysis. These drugs are have of high permeability capacity because of low interfacial tension. This review focuses on the basic concept such as formulation, characterization, component and structure of microemulsion.


Keywords: Microemulsion, Lipophilicity, Solubilization, Bioavailability, Phase- behaviour, Thermodynamically stable.

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Santosh Kumar R, Mukherjee J. Microemulsions: Platform for Improvement of Solubility and Dissolution of Poorly Soluble Drugs. JDDT [Internet]. 7Jan.2020 [cited 29Oct.2020];9(4-A):908-10. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3789