Fabrication of drug eluting medical device for treating stenosis by 3D printing and dip coating using aspirin as a model drug

  • Rajesh Akki Assistant Professor, Department of Pharmaceutics, Hindu college of Pharmacy, Amaravathi Road, Guntur-522002, Andhra Pradesh, India.
  • MUNAGALA GAYATRI RAMYA University College of Pharmaceuical Sciences, Acharya Nahajuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India
  • K. Chinni Krishna Assistant Professor, Department of Pharmaceutics, Hindu college of Pharmacy, Amaravathi Road, Guntur-522002, Andhra Pradesh, India.
  • Singaram Kathirvel National College of Pharmacy, Manassery P.O, Mukkam, Kozhikode-673602, Kerala

Abstract

3D printing is a new innovative manufacturing method for fabrication of customized medical devices. The customized medical devices & long-lasting implantable devices.has increasing demand for addressing some critical cases in surgeries.


The main aim of this work was to explore the potential of 3D printing in Fabrication of medical devices and prosthetics. The characters of the polymers, the features of softwares were studied.


The study showed that drug loading into filament through hot melt extrusion and followed by 3D printing has many defects such as denaturing of drugs at higher printing temperatures.


The invention discloses the dip coating process  after fabrication of a 3D printed polymer structure. The drug release depends up on the surface area of the device, coated polymer, concentration of drug and thickness of the coat.


The method for preparing the personalized drug eluting coronary stent / Bone wedges / Braces comprises the step that according to image data of coronary angiogram or volume rendered data from CT scans. The designing was done by adopting a QCA technique for measuring the diameter of a diseased coronary artery and reconstructing in a three-dimensional manner. According to indexes such as lesion vascular diameter, lesion length and lesion vascular pattern, a personalized coronary stent can be made for each patient in a customized manner and a stent most suitable for the lesion state of a patient can be prepared.


Keywords: 3D printing, manufacturing method, Fabrication of medical devices

Downloads

Download data is not yet available.

References

1. Anuja R. Shah and R. K. Goyal, Current Status of the Regulation for Medical Devices ,Indian J Pharm Sci. 2008 Nov-Dec; 70(6): 695–700.
2. Bogusz Stępak, Arkadiusz J. Antończak, and Krzysztof M. Abramski, Optimization of femtosecond laser cutting of a biodegradable polymer for medical devices manufacturing ,Photonics letters of poland, Vol. 8 (4), 116-118 (2016)
3. Sebastian Białasz1,and Tomasz Klepka, Simulation of the medical syringe injection moulding process ,MAETC web of conferences 252,05016(2019)
4. Yang Lei, Xin Chen, Lei Zhang, Lei Li, Shuangzhu Kang, Chengjin Wang and Wei Sun. Additive Manufacturing in Vascular Stent Fabrication
MATEC Web of Conferences 253, 03003 (2019)
5. Antonio J. Guerra , Paula Cano , Marc Rabionet , Teresa Puig and Joaquim Ciurana, Article 3D-Printed PCL/PLA Composite Stents: Towards a New Solution to Cardiovascular Problems, Materials 2018, 11, 1679
6. CN105877881A 2016-08-24 CN105877881A Application
7. Kathryn, Injection Molding vs. 3D Printing
8. www.investopedia.com/terms/1/3d-printing.asp
9. Robert Breitbach Consulting, Headhunter Printing Industry , , www.breitbach.com/h/headhunter-printing.htm
10. Barry Berman ,3-D printing: The new industrial revolution ,
11. Antonio J. Guerra , Paula Cano , Marc Rabionet ,Teresa Puig and Joaquim Ciurana 3D-Printed PCL/PLA Composite Stents: Towards a New Solution to Cardiovascular Problems
12. Yang Lei, Xin Chen, Lei Zhang, Lei Li, Shuangzhu Kang, , Chengjin Wangand Wei Sun Additive Manufacturing in Vascular Stent Fabrication
13. Sam Davies, FDA-approved 3D printed implants just the start as Osseus prepares to go international "We are trying to ride the wave of 3D printing.
14. Xiaohualiu and Peter x. ma, Polymeric Scaffolds for Bone Tissue Engineering, Annals of Biomedical Engineering, Vol. 32, No. 3, March 2004 (©2004) pp. 477–486.
15. Bret D. Ulery, Lakshmi S. Nair, Cato T. Laurencin. Biomedical Applications of Biodegradable Polymers, journal of polymer science part b: polymer physics 2011, 49, 832–864
16. A. Ashwin Kumar, Karthick. K, and K. P. Arumugam, Biodegradable Polymers and Its Applications International Journal of Bioscience, Biochemistry and Bioinformatics, Vol. 1, No. 3, September 2011
17. Anezka Lengalova, Alenka Vesel, Yakai Feng, and Vitor Sencadas Biodegradable Polymers for Medical Applications Hindawi Publishing Corporation International Journal of Polymer Science Volume 2016,
18. Shenguo Wang, Jianzhong Bei Biodegradable Polylactone-family Polymers and Their Applications in Medical Field 8th arab international conference on polymer science & technology 27 – 30 November 2005, Cairo-Sharm El-Shiekh, EGYPT
19. Mark Chasin , Robert Langer, Textbook of Biodegradable Polymers as Drug Delivery Systems
20. Gregory I. Peterson, Andrey V. Dobrynin, and Matthew L. Becker Biodegradable Shape Memory Polymers in Medicine Adv. Healthcare Mater. 2017, 1700694
21. Mihai Rusu, Mihaela Ursu, Daniela Rusu. Poly(vinyl chloride) and Poly(e-caprolactone) Blends for Medical Use. Journal of Thermoplastic Composite Materials, SAGE Publications (UK and US), 2006, 19 (2), pp.173-190.
22. Bret D. Ulery, Lakshmi S. Nair, and Cato T. Laurencin, Biomedical Applications of Biodegradable Polymers, J Polym Sci B Polym Phys. 2011 Jun 15; 49(12): 832–864.
23. A. ANAND, R. PUNDIR, C. S. PANDIAN, S. SARAF AND H. GUPTA Cefoperazone Sodium Impregnated Polycaprolactone Composite Implant for Osteomyelitis Indian J. Pharm. Sci., 2009, 71 (4): 377-381
24. Jenny Hollander , Natalja Genina , HarriJukarainen , Mohammad Khajeheian , Ari Rosling , Ermei Makil , Niklas Sandler ,Three-Dimensional Printed PCL-Based Implantable Prototypes of Medical Devices for Controlled Drug Delivery
25. Fileinfo.com https://fileinfo.com/extension/dicom
26. www.microdicom.com/
27. MedDream DICOM Viewer – Softneta www.softneta.com/meddream.html
28. https://www.slicer.org/wiki/Documentation/4.10/FAQ
29. Evans, Brian. Practical 3D Printers: The Science and Art of 3D Printing. apress. ISBN 978-1-4302-4393-9.
30. BEGINNER’S GUIDE TO 3D PRINTING ,VERSION 0.1 ,THINK3D TEAM
31. Feuerbach T, Kock S, Thommes M Characterization of fused deposition modeling 3D printers for pharmaceutical and medical applications.
Pharm Dev Technol. 2018 Dec; 23(10):1136-1145
32. CA2276096C
33. Margarethe Richter, Christian Schneider ,Thermo Fisher Scientific ,Low-Temperature Hot-Melt Extrusion of Acetaminophen with EVA, 5781 Van Allen Way , Carlsbad, CA 92008 , thermofisher.com
34. Cheng L, Guo S, Wu W. Characterization and in vitro release of praziquantel from poly(ε-caprolactone) implants. Int J Pharm. 2009; 377:112-119.
35. Aspirin-loaded P(3HO)/P(3HB) blend films: Potential materials for biodegradable drug-eluting stents Patrick M. Aja , Onu Patience , Antoinette N. C. Okaka , Udu A. Ibiam Bioinspired, Biomimetic and Nanobiomaterials Volume 2 Issue BBN3
36. M. Shoja, K. Shameli, M. B. Ahmad , Z. Zakaria Preparation and characterization of poly (εcaprolactone)/tio2 micro-composite,
Digest Journal of Nanomaterials and Biostructures 2015; 10(2):471 – 477
37. Sinha VR, Bansal K, Kaushik R, Kumria R, Trehan A. Poly-ε-caprolactone microspheres and nanosperes: an overview. Int J Pharm. 2004; 278:1-23.
Statistics
55 Views | 64 Downloads
How to Cite
1.
Akki R, RAMYA MG, Krishna KC, Kathirvel S. Fabrication of drug eluting medical device for treating stenosis by 3D printing and dip coating using aspirin as a model drug. JDDT [Internet]. 15Dec.2019 [cited 31Oct.2020];9(6-s):148-54. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3767