Estimation of D-dimer Level among Sudanese Women under Contraceptive Pill

  • Zeinab Atif Ahmed Osman Faculty of Medical Laboratory Sciences, National University, Sudan
  • Sara Elsadig Babiker MRCOG, Sultan Qaboose Hospital, Slalah, Oman
  • Nihad Elsadig Babiker Faculty of Medical Laboratory Sciences, National University, Sudan


Contraceptives are intentional prevention of conception through the use of various devices sexual practices, chemicals, drugs or surgical procedures become a contraceptive if its purpose is to prevent a woman from becoming pregnant. This is a cross sectional study conducted at ALnow Hospital Khartoum, Sudan,  the study aimed to estimate D.dimer levels among Sudanese women take contraceptive pill.    50 Women uses contraceptive pill used as a cases and 50 apparently health women were used as a control. Three   ml of venous blood samples were collected from each subject in 3.8% tri-sodium citrate (9:1 vol/vol) for D-dimer analysis.  The study revealed that was clearly significant increase in D.dimer in women take oral contraceptive pill (p.value 0.000), also the study concluded that D-dimer level was increased in users oral contraceptive Sudanese women,  that is increase the coagubility of the blood  and might be become as a risk factor.  

Keywords: Contraceptive pills, D.dimer, coagubility.


Download data is not yet available.


1- Mcevoy G K. AHFS Drug Information. Bethesda, MD: American Society of Health systems Pharmacists 2004.
2- DHMH/FHA/CMCH Maryland Family Planning & Reproductive Health Program Clinical Guidelines Oral Contraceptive Methods – Revised 4/15/2012 Page 1 Of 15.
3- Archer DF, Bigrigg A, Smallwood GH, et al. Transdermal delivery of combined hormonal contraception. Dovepress 2004; 69(3):189–195.
4- Roger S. Riley, Andrea R. Gilbert, Justin B. Dalton, Sheela Pai, Richard A, McPherson. Widely Used Types and Clinical Applications of D-Dimer Assay, Laboratory Medicine 2016; 47(2):90–102.
5- Joanna Urbaniak, Hanna Zielin´ska-Bliz´niewska , Jarosław Miłon´ski, Piotr Pietkiewicz, Krzysztof Kus´mierczyk, Jurek Olszewski. Effects of oral contraceptives on selected parameters of the homeostatic control system in young women having a sudden disorder of the auditory and/or balance system. Eur Arch Otorh 2015; 272:321–326.
6- Husaynee AJ, Kashmoola MA. Effect of combined oral contraceptive pills on some haemostatic parameters. Ann. Coll. Med. Mousl 2007; 33(1&2): 66-69.
7- Meijers JC, Middeldorp S, Tekelenburg W, van den Ende AE, Tans G, Prins MH et al. Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis. a randomized cross-over study of two low-dose oral contraceptives. Thromb Haemost. 2000; 84(1):9-14.
8- Sitruk-Ware R. New progestagens for contraceptive use. Hum Reprod Update 2006; 12(2):169–178.
9- Van Vliet HA, Frolich M, Christella M et al. Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens. Hum Reprod 2005; 20(2):563–568.
10- Carolyn L. Westhoff AB, Andrew Eisenberger c, Rosalind Tanga, Serge Cremers d,Lisa V. Grossmanb, Malcolm C. Pikee. Clotting factor changes during the first cycle of oral contraceptive use. Contraception 2016; (93):70–76
11- van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP, Doggen CJ, Rosendaal FR. The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case–control study. BMJ 2009; 339:b2921.
12- klipping C, Duijkers I, Parke S, Mellinger U, Serrani M, Junge W. Hemostatic effects of a novel estradiol-based oral contraceptive, an open-label, randomized, crossover study of estradiol valerate/dienogest versus ethinylestradiol/ levonorgestrel. Drugs R D 2011; 11(2):159-170.
13- Tchaikovski SN, Rosing J. Mechanisms of estrogeninduced venous thromboembolism. Thromb Res 2010; 126(1):5–11.
14- Tanis BC, Rosendaal FR, Venous and arterial thrombosis during oral contraceptive use: risks and risk factors. Semin Vasc Med 2003; 3(1):69–84.
15- Dhmh Fha Cmch. Maryland Family Planning & Reproductive Health Program Clinical Guidelines Oral Contraceptive Methods 2012; 1-15.
58 Views | 89 Downloads
How to Cite
Osman ZAA, Babiker SE, Babiker N. Estimation of D-dimer Level among Sudanese Women under Contraceptive Pill. JDDT [Internet]. 15Dec.2019 [cited 31Oct.2020];9(6-s):53-7. Available from: