Liquisolid Compacts: A Review
Bioavailability is mostly effected by drug dissolution and its release from the dosage form, and it mainly depends on solubility of drug. For the development of new pharmaceutical products the major issue any pharmaceutical industry faces is solubility that ultimately results in low bioavailability. To enhance the solubility of poorly soluble drugs liquisolid compacts is one of the impending techniques. This technique involves a preparation where the liquid drug present in the form of a solution or suspension is transformed into a non sticky, dry, compactable, free-flowing powders, this is accomplished by adding certain coating agents and carriers that are appropriate. This technique with comparison to conventional tablets has the capability of enhancing the absorption of less soluble drugs in its molecularly dispersed form, rate of dissolution, aqueous solubility thereby increasing its bio availability by using less production costs and simpler manufacturing processes.
Keywords: Bioavailabity enhancement, Coating agents, Carriers, Solubility enhancement, Liquisolid compacts, Dissolution
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