Liquisolid Compacts: A Review

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed To Be University) Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India
  • Jampana Divija Sai GITAM Institute of Pharmacy, GITAM (Deemed To Be University) Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India

Abstract

Bioavailability is mostly effected by drug dissolution and its release from the dosage form, and it mainly depends on solubility of drug. For the development of new pharmaceutical  products the major issue any pharmaceutical industry faces is solubility that ultimately results in low bioavailability. To enhance the solubility of poorly soluble drugs liquisolid compacts is one of the impending techniques. This technique involves a preparation where the liquid drug present in the form of a solution or suspension is transformed into a non sticky, dry, compactable, free-flowing powders, this is accomplished by adding certain coating agents and carriers that are appropriate. This technique with comparison to conventional tablets has the capability of enhancing the absorption of less soluble drugs in its molecularly dispersed form, rate of dissolution, aqueous solubility thereby increasing its bio availability by using less production costs and simpler manufacturing processes.


Keywords: Bioavailabity enhancement, Coating agents, Carriers, Solubility enhancement, Liquisolid compacts, Dissolution

Downloads

Download data is not yet available.

References

1. Peddi MG. Novel drug delivery system: liquid-solid compact. J Mol Pharm Org Proc Res 2013; 1:1-5.
2. Baby JN, Manjila SB, Bijen EN, Constantine I, Pramod K, Valsalakumari j. Design and technology of liquisolid compacts. J Appl Pharm Sci 2013; 3:111-9.
3. Pawar JD, Jagtap RS, Doijad RC, Pol SV, Desai JR, Jadhav VV, et. al. Liquisolid compacts: a promising approach for solubility enhancement. J Drug Delivery Ther 2017; 7:6-11.
4. Azarmi S, Farid D, Azodi-Deylami S, Ghaffari F, Nokhodchi A. The influence of Thermal treatment on thne release behaviour of diclofenac sodium from an acrylic material. Pharm Dev Technology 2005; 10:233-9.
5. Nokhodchi A, Y Javadzadeh, L Mosaalrezaei. Liquisolid technique for sustaining the drug release from compacts. J Pharm Res 2007; 59:20-8.
6. Sanka Krishna, SravanthiPoienti, Abdul Bari Mohd, Prakash V Diwan. Improved oral delivery of clonazepam through liquisolid powder compact formulation: in vitro and ex vivo characterization. Powder Technol2014; 256:336-44.
7. Komala DR, Janga KY, JukantiR. Competence of raloxifene hydrochloride loaded liquisolid compacts for improved dissolution and intestinal permeation. J Drug Delivery Sci Technol2015; 30:232-41.
8. Khaled KA. Formulation and evaluation of hydrocholothiazideliquisolid tablets. Saudi Pharm J 1998; 6:39-49.
9. Vajir S, Sahu V, Ghuge n, Bakde BV. Liquisolid compacts: a new technique for enhancement of drug dissolution. Int J Pharm Res Dev 2012; 4:302-6.
10. Panda S, Varaprasad R, Priyanka K, Swain RP. Liquisolid technique a novel approach for dossage form design.Int J Appl Pharm 2017; 9:8-14.
Sanjay PD, Deepak M, Bhanudas SR. Liquisolid technology: a technique for formulation with enhanced bioavailability. World J Pharm Sci 2013; 3:368-87.
Statistics
39 Views | 37 Downloads
How to Cite
1.
Santosh Kumar R, Divija Sai J. Liquisolid Compacts: A Review. JDDT [Internet]. 6Dec.2019 [cited 29Oct.2020];9(4-A):880-3. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3706