Particle Engineering Techniques: A Boon in Enhancing Dissolution Rate of Poorly Water Soluble Drugs

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed To Be University) Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India
  • T. Manohara Sai GITAM Institute of Pharmacy, GITAM (Deemed To Be University) Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India

Abstract

For any dosage forms enhancing dissolution is the first criteria i.e. it should give increased bioavailability in order to provide onset of action. In market many poorly soluble drugs are available which are having problem of low solubility. Low solubility of these poorly water soluble drugs are the main issue factor in preparing dosage forms of these drugs as with low solubility enhanced or effective dissolution to reach therapeutic effect is difficult. To overcome these problems there are main engineering techniques came in market which helps in enhancing the dissolution of these drugs. Some of the common use techniques are cryogenic, super critical fluid technology, evaporative precipitation into aqueous solution, nano- milling methods were developed based on the drug properties and required nanoparticles character. Making use of these techniques has increases the in vitro dissolution rates and in vivo bioavailability of many poorly water soluble drugs. This review highlights about the materialistic availability of particle engineering processes recently reported in the literature for enhancing the dissolution properties of poorly water soluble drugs.


Keywords: Solubility. Dissolution Rate, Poorly Soluble Drugs, Particle Engineering Techniques

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References

1. Radtke M. Pure drug nanoparticles for the formulation of poorly soluble drugs. New Drugs 2001; 3:62–68.
2. Noyes AA, Whitney WR. The rate of solution of solid substances in their own solutions. J Am Chem Soc 1897; 19:930–934.
3. Singla AK, Garg A, Agarwal D. Paclitaxel and its formulations. Int J Pharm 2002; 235: 179– 192.
4. Blagden N, Matas MD, Gavan PT, York P. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews 2007; 59:617–630.
5. Almarsson O, Zaworotko MJ. Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co‐crystals represent a new path to improved medicines?. Chem Commun 2004:1889-1896.
6. Beach S, Lathan D, Sidgwick C, Hanna M, York P. Control of the physical form of Salmeterol Xinafoate. Org Proc Res Dev 1999; 3:370-376.
7. Jung J, Perrut M. Particle design using supercritical fluids: Literature and patent survey. J Supercrit Fluids 2001; 20:179-219.
8. Pace GW, Vachon MG, Mishra AK, Henrikson IB and Krukonis V. Processes to generate submicron particles of water‐insoluble compounds. US Patent:6,177,103:2001.
9. Jung J, Perrut M. Particle design using supercritical fluids: literature and patent survey. J Supercrit Fluids 2001; 20:179–219.
10. Loth H, Hemgesberg E. Properties and dissolution of drugs micronized by crystallization from supercritical gases. Int J Pharm 1986; 32:265.
11. Foster NR, Dehghani F, Charoenchaitrakool M, Warwick B. Application of dense gas techniques for the production of fine particles. AAPS Pharm Sci 2003; 5:105–111
12. Mishima K, Yamaguchi S, Umemot H. Patent JP 8104830, 1996.
13. Jung J, Perrut M. Particle design using supercritical fluids: literature and patent survey. J Supercrit Fluids 2001; 20:179–219.
14. Werling JO, Debenedetti PG. Numerical modelling of mass transfer in the supercritical antisolvent process: miscible conditions. J Supercrit Fluids 2000; 18:11.
15. Zhao X, Zu Y, Li Q, Wang M, Zu B, Zhang X, Jiang R and Chunlin Z. Preparation and Characterization of Camptothecin Powder Micronized By a Supercritical Antisolvent (SAS) Process. J Supercrit Fluids. Article in press. Pages 1-8.
16. Chang YP, Tang M, Chen YP. Micronization of Sulfamethoxazole using the Supercritical Anti-Solvent Process. J Mater Sci 2008; 43:2328–35.
17. Krukonis VJ, Gallagher PM, Coffey MP. Gas anti‐solvent recrystallization process. Patent US 5,360,478, 1994.
18. Charoenchaitrakool M, Polchiangdee C, Srinophakun P. Production of Theophylline and Polyethylene Glycol 4000 Composites using Gas Anti-Solvent(GAS) Process. Materials Letters 2009; 63:136–138.
19. Klugea J, Fusaroa F, Muhrerb G, Thakurb R, Mazzotti AM. Rational Design of Drug Polymer Co‐Formulations by CO2 Anti‐Solvent Precipitation. J Supercrit Fluids 2009; 48: 176–182.
20. Magnan C, Badens E, Commenges N, Charbit G. Soy Lecithin Micronization by Precipitation with a Compressed Fluid Antisolvent: Influence of Process Parameters. J Supercrit Fluids 2000; 19:69–77.
21. Weidner E, Knez Z, Novak Z. Process for the production of particles or powders. Patent WO 95/21688, 1995.
22. Sencar Bozic P, Srcic S, Knez Z, Kerc J. Improvement of nifedipine dissolution characteristics using supercritical CO2. Int J Pharm 1997; 148:123‐130.
23. Briona M, Jasparta S, Perroneb L, Piel GA, Evrarda B. The Supercritical Micronization of Solid Dispersions by Particles from Gas Saturated Solutions using Experimental Design. J Supercrit Fluids 2009; 51:50–56.
24. Pyo D. Two Different Shapes of Insulin Microparticles Produced by Solution Enhanced Dispersion Supercritical Fluid (SEDS) Process. Bull Korean Chem Soc 2009; 30(5):1215.
25. Leuenberger H. Spray freeze drying: The process of choice for low water soluble drugs. J Nanoparticle Res 2002; 4:111-119.
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Santosh Kumar R, Manohara Sai T. Particle Engineering Techniques: A Boon in Enhancing Dissolution Rate of Poorly Water Soluble Drugs. JDDT [Internet]. 18Dec.2019 [cited 24Oct.2020];9(4-A):897-00. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3674