Phytochemical and Anti-Inflammatory Evaluation of Herbal Gel Prepared from Bark Extract of Mesua Ferrea Linn
The present research work involves formulation of herbal gel containing stem bark extracts of Mesua ferrea Linn and its evaluation for in vitro anti-inflammatory activity. The gel formulations were prepared using ethanolic extracts along with different polymer. The physiochemical parameters of formulations like; pH, viscosity and spreadability etc. also evaluated. Phytochemical analysis revealed presence of phenols, flavonoids and alkaloids, etc. The ethanolic extracts showed appreciable anti-inflammatory activity compared to the standard drug. Study confirmed that potential anti-inflammatory formulation can be developed from bark extract of Mesua ferrea Linn.
Keywords: Mesua ferrea Linn., Anti-inflammatory, Herbal Gel, Phytochemical, Albumin denaturation.
2. Vonkeman HE, van de Laar M. Non-steroidal anti-Inflammatory drugs: adverse effects and their prevention. Semin Arthritis Rheum 2010; 39:294-312.
3. Manoj Kumar Chahar, Sanjaya Kumar DS, Geetha L, Lokesh T, Manohara KP. Mesua ferrea L. A review of the medical evidence for its phytochemistry and pharmacological actions. Afr J Pharm Pharmacol 2013;7:211-9.
4. Manjunath BK, Syed murtuza, Divakara, Archana, Sarvani, Steffina, et al. Antioxidant and anti-inflammatory potency of Mesua ferrea Linn. Indian J Appl Res 2013;8:3.
5. Vandana Rawat, Kumud Upadhyaya. Evaluation of antimicrobial activity and preliminary phytochemical screening of Mesua ferret seeds extract. Indian J Nat Prod 2013;6:17-26.
6. Harborne JB. Phytochemical methods, A guide to modern techniques of plant analysis, Spring Publisher, 2008, 40-96, 107-138, 151-179, 235-249.
7. Harborne JB. Phytochemical methods: a guide to modern techniques of plant Analysis. 3rd ed. London: Chapman and Hall; 1988. p. 117.
8. Trease GE, Evans WC. Pharmacognosy. 12th ed. ELBS Publication, Baillier Tindall, East Bourne; 1996. p. 539.
9. Chang C, Yang M, Wen H, Chern J. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 2002;10:178–82.
10. Zhishen J, Mengcheng T, Jianming W. The determination of flavonoid content in mulberry and their scavenging effects on superoxide radicals. Food Chem 1999; 64:555–9.
11. Kumar L, Verma R. In vitro evaluation of topical gel prepared using natural polymer. Int J Drug Delivery 2010, 2: 58-63.
12. Multimer MN, Riffskin C, Hill JA. J Am Rheological and Mechanical Properties of Pharmaceutical Gels. Medicated Systems-Relevance to Hydration Properties and Drug Release. Boll. Chim. Farm. 2001; 140 (5): 337 -44.
13. Mizushima Y, Kobayashi M. Interaction of anti‐inflammatory drugs with serum proteins, especially with some biologically active proteins. J Pharm Pharmacol 1968; 20:169‐73.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).