Edible Vaccines: Trigger of Body’s First Line Defense

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed to be University)
  • Ch. Chandra Kiran

Abstract

Vaccines are used as protective agents from various diseases. The major reason to prepare vaccines are to digest the macromolecule of proteins in stomach considering of high pH . To overcome this issue a scientist named Arntzen developed the theory of edible vaccines. EVs are developed by genetic technology; in this the genes are introduced directly to the plants in various methods. The developed plant contains coded protein which acts as a vaccine. Purchasing at low cost leads to the prevention of various diseases like malaria, measles, hepatitis B , cholera, HIV and anthrax    


Keywords: Edible vaccines, Antigens, Oral immunization, Immunity.

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Author Biographies

Rada Santosh Kumar, GITAM Institute of Pharmacy, GITAM (Deemed to be University)

GITAM Institute of Pharmacy, GITAM (Deemed To Be University) Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.

Ch. Chandra Kiran

GITAM Institute of Pharmacy, GITAM (Deemed To Be University) Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.

References

1. Charmi PS, Manisha NT, Urmila DV, Vishwash JJ. Edible vaccine: A better way for immunization. Int J Curr Pharm Res 2011;3:53-6.
2. Morr TS, Gomez LM, Palmer KE. Edible vaccines: A concept comes of age. Trends Microbiol 1998;6:449-53.
3. Daniell H, Streatfield SJ, Wycoff K. Medical molecular farming: Production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 2001;6(5):219-26.
4. Hafiz E, Eyob H. Review on edible vaccine. Acad J Nutr 2015;4:40-9.
5. Hudu SA, Shinkafi SH, Shuaibu U. An overview of recombinant vaccine technology, adjuvants and vaccine delivery methods. Int J Pharm Sci 2016;8:19-24.
6. Goldblatt D, Ramsay M. Immunization in domestic animal. Oxford Text Book of Medicine. 4th ed. United Kingdom: Oxford University Press; 2003.
7. LevineMM. Enteric infections and the vaccines to counter them: Future directions. Natl Med 2006;24(18):3865-73.
8. Yoshida T, Kimura E, Koike S, Nojima J, Futai E, Sasagawa N, et al. Transgenic rice expressing amyloid ß-peptide for oral immunization. Int J Biol Sci 2011;7:301-7.
9. Arakawa T, Chong D, Langridge W. Transgenic plants for the production of edible vaccine and antibodies for immunotherapy. Nat Biotechnol 1998;16:292-7.
10. Sharma M, Sood B. A banana or a syringe: Journey to edible vaccines. J Microbiol Biotechnol 2011;27(3):471-7.
11. Akhilesh T,Anjali K. Edible vaccines: Let thy food be thymedicine. Int J Pharmacol Screen Methods 2014;4:105-8.
12. Lal P, Ramachandran VG, Goyal R, Sharma R. Edible vaccines: Current status and future. Indian J Med Microbiol 2007;25:93-102.
13. Das DK. Plant derived edible vaccines. Curr Trends Biotechnol Pharm 2009;3:113-27.
14. Webster DE, Thomas MC, Strugnell RA, Dry IB, Wesselingh SL. Appetising solutions: An edible vaccine for measles. Med J Aust 2002;176:434-7.
15. Waghulkar, VM. Fruit derived edible vaccines: Natural way for the vaccination. Int J Pharmtech Res 2010;2:2124-7.
16. Singh BD. Biotechnology. 1st ed. India: Kalyani Publishers; 1998.
17. Madhumita N, Deepak V, Pallavi U. Edible vaccines - A review. Int J Pharmacother 2014;4:58-61.
18. Krishna C, Jonnala UK, Sri R. Edible vaccines. Sriramachandra J Med 2006;1:33-4.
19. Jacob SS, Cherian S, Sumithra TG, Raina OK, Sankar M. Edible vaccines against veterinary parasitic diseases – Current status and future prospects. Vaccine 2013;31(15):1879-85.
20. Lossl A, Waheed M. Chloroplast-derived vaccines against human diseases: Achievements, challenges and scopes. J Plant Biotechnol 2011;9:527-39.
21. Swapna LA. Edible vaccines: A new approach for immunization in plant biotechnology. Sch Acad J Pharm 2013;2:227-32.
22. Streatfield SJ. Mucosal immunization using recombinant plant-based oral vaccines. Methods 2006;38(2):150-7.
23. Takahashi I, Nochi T, Kunisawa J, Yuki Y, Kiyono H. The mucosal immune system for secretory IgA responses and mucosal vaccine development. Inflamm Regen 2010;30:40-7.
24. de Aizpurua HJ, Russell-Jones GJ. Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding. J Exp Med 1988;167(2):440-51.
25. LangridgeWH. Edible vaccines. Sci Am 2000;283(6):66-71.
26. Franklin CI, Trieu T, Gonazales RA, Dixon RA. Plant regeneration from seeding explants of green bean (Phaseolus vulgaris L.) via organogenesis. Plant Cell Tissue Organ Cult 1991.
27. De la Riva GA, Gonzalez-Cabrera J, Vasquez R, Ayra-Pardo C. Agrobacterium tumefaciens: A natural tool for plant transformation. Electron J Biotechnol 1998;1:118-32.
28. Lee RW, Strommer J, Hodgins D, Shewen PE, Niu Y. Towards development of an edible vaccine against bovine pneumatic pasteurellosis using transgenic white clover expressing a Mannheimia fusion protein. Infect Immun 2001;69:5786-93.
29. Plantharayil BA. Plant based edible vaccines against poultry diseases: Areview. Adv Anim Vet Sci 2014;2:305-11.
30.Taylor NJ, Fauquet CM. Microparticle bombardment as a tool in plant science and agricultural biotechnology. DNA Cell Biol 2002;21(12):963-77.
31. Maliga P. Engineering the plastid genome of higher plants. Curr Opin Plant Biol 2002;5(2):164-72.
32. Ramshaw IA, RamsayAJ. The prime-boost strategy: Exciting prospects for improved vaccination. Immunol Today 2000;21(4):163-5.
33. Yoshimatsu K, Kawano N, Kawahara N, Akiyama H, Teshima R, Nishijima M. Current status in the commercialization and application of genetically modified plants and their effects on human and livestock health and phytoremediation. Yakugaku Zasshi 2012;132(5):629-74.
34. HuyNX, KimSH,YangMS, KimTG. Immunogenicity of a neutralizing epitope from porcine epidemic diarrhea virus: M cell targeting ligand fusion protein expressed in transgenic rice calli. Plant Cell Rep 2012;31(10):1933-42.
35. WangY, Shen Q, JiangY, SongY, Fang L, Xiao S, et al. Immunogenicity of foot-and-mouth disease virus structural polyprotein P1 expressed in transgenic rice. J Virol Methods 2012;181(1):12-7.
36. Loza-Rubio E, Rojas-Anaya E. Vaccine production in plant systems – An aid to the control of viral diseases in domestic animals: A review. Acta Vet Hung 2010;58(4):511-22.
37. Dauvillée D, Delhaye S, Gruyer S, Slomianny C,Moretz SE, d’Hulst C, et al. Engineering the chloroplast targeted malarial vaccine antigens in Chlamydomonas starch granules. PLoS One 2010;5(12):e15424.
38. Streatfield SJ, Jilka JM, Hood EE, Turner DD, Bailey MR, Mayor JM, et al. Plant-based vaccines: Unique advantages. Vaccine 2001;19(17-19):2742-8.
39. William S. A review of the progression of transgenic plants used to produce plant bodies for human usage. J Young Invest 2002;4:56-61.
40. Renuga G, Tandipani AB, Arur AK. Transgenic banana callus derived recombinant cholera toxin B subunit as potential vaccine. Int J Curr Sci 2014;10:61-8.
41. Doshi V, Rawal H, Mukherjee S. Edible vaccines from GM crops. J Pharm Sci Innov 2013;2:1-6.
42. Rupali RK, Sumit K, Uttam K. Edible vaccine: Aprospective substitute for better immunization in future. Int J Pharm Bio Sci 2012;3:948-55.
43. Tiwari S, Verma PC, Singh PK, Tuli R Plants as bioreactors for the production of vaccine antigens. Biotechnol Adv 2009;27:449-67.
44. Wang L, Goschnick MW, Coppel RL. Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge. Infect Immun 2004;72:6172-5.
45. Huang Z, Dry I, Webster D, Strugnell R, Wesselingh S. Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice. Vaccine 2001;19:2163-71.
46. Polack FP, Auwaerter PG, Lee SH, Nousari HC, Valsamakis A, Leiferman KM, et al. Production of atypical measles in rhesus macaques: Evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody.
Nat Med 1999;5:629-34.
47.Prakash CS. Edible vaccines and antibody producing plants. Biotechnol Dev Monitor 1996;27:10-3.
48. Karasev AV, Foulke S, Wellens C, Rich A, Shon KJ, Zwierzynski I, et al. Plant based HIV-1 vaccine candidate: Tat protein produced in spinach. Vaccine 2005;23(15):1875-80.
49. Kim TG, Galloway DR, Langridge WH. Synthesis and assembly of anthrax lethal factor-cholera toxin B-subunit fusion protein in transgenic potato. Mol Biotechnol 2004; 28(3):175-83.
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How to Cite
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Santosh Kumar R, Chandra Kiran C. Edible Vaccines: Trigger of Body’s First Line Defense. JDDT [Internet]. 30Aug.2019 [cited 23Oct.2020];9(4-A):811-4. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3619

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