Parenteral Suspensions: Stability Enhancing Liquid Dosage Forms
Oral route is the most common preferred route. In market number of drugs are available with solubility problem. It is difficult to prefer oral conventional dosage form other drugs on this less solubility which result in loss bioavailability. Parenteral suspensions are dosage forms containing drugs having low solubility. Drugs in suspension form increase the solubility, stability of the drugs. Drugs in sulfonation form have large surfaces areas. Parenteral suspensions provides onset of action for prolonged line on compared to solution.
Keywords: Stability, Parenteral suspensions, Syringebility, Dosage forms.
2. M.J.Akers, A.L. Fites, R.L. Robinson. Journal of parenteral science and Technology, 1987,41: 88.
3. A. Liberman, Martin, M. Rieger, Banker. Gilbent’s Pharmaceutical Dosage forms Dispersed systems, vol 2, Marcel Dekker; 1996. 285.
4. Carstensen TJ, Theory of Pharmaceutical systems, volII, Academic press; NY, 1973. 59.
5. 5. E. Avis Kenneta, Lachman leon. Theory and Practice of Industrial Pharmacy. 3rd ed. Bombay: Varghese publishing; 1976. 654.
6. R.A. Nash. The Pharmaceutical suspension, PartI, Drug cosmet, Ind, 1965, 97, 843.
7. Lippincolt, K. Williams. Remington, The Science & practice of pharmacy, Parenteral Preparation, 20th ed., volume I, Phelabelphia: ISE publication; 2000. 804.
8. W.I. Higuchi, J.S. Swarbrick, A.P. Simonelli, Martin. Particle phenomenon and course dispersious, Remington’s Pharmaceutical science. 16th ed. Easton PA: mark publishing co; 1980.294.
9. E.S. Antal, C.F. Disk, C.E. Wright, I.R. Welshman. Comparative bioavailability of two medroxy progesterone acetate suspensions. Int. J. Pharm. 1989, 54:33-39.
10. J.F. Quay, J.F. Stucky. Non aqueous cephalosporin suspension for parenteral Administration. J..Pharm. Sci. 1989, 11:16021606.
11. G.A. Brazeau, H.L. Fung. Mechanics of retaining kinase release from isolated rat skeletal museles damaged by propylene glucol and ethanol. J. Pharm. Sci. 1990, 79: 397.
12. K.E. Avis. Parenteral preparations in Remingtons pharmaceutical science 16th ed. Mark publishing; 1980. 1467.
13. British Pharmacopoela, London, 1993 Appendix XVIC, PPA191192.
14. R. Huettenrauch. Stabilization of suspension, 1989, DD 209970.Al 840530, 8PP
15. R.Arxy. Physician’s Desk Reference 48th ed. Medical economics data. Production Company, montvate, NJ 1999. 954.
16. R.Arxy. Physician’s Desk Reference 48th ed. Medical economics data. Production Company, Montvate, NJ 1994. 2170.
17. J. Broadhead, Edmond, S.K. Royan, C.T. Rhods. The Spray during at Pharmaceuticals Drug Dev. Ind. Pharm. 1992, 18: 1169-1206.
18. G.S. Banker, E.T. Rhodes. Modern Pharmaceutics marcel Dekker, New York, 1979. 466.
19. N.A. Williams, G.P. Polli The lyophilization of pharmaceutical Aliterative review Parent. J. Sci. Technol. 1984, 2(38): 48-59.
20. M. Nyamrk, vFrank. Journal of pharmaceutical science. 1999,88: 861.
21. S.C. Harvey. Journal of pharmaceutical science. 1998, 87: 175.
22. Chien, W. Yiew Journal of parenteral science and technology.1981, 35: 106.
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