A Review on Study of Hepatoprotective Activity of Chenopodium Album Linnon CCl4 Induced Hepatotoxicity in Rats

  • Himanshu Jain
  • Yogesh Kumar Sharma


The hepatoprotective activity of Chenopodium album Linn leaves against carbon tetrachloride (CCl4)-induced hepatotoxicity was investigated. Possibilities of Rat hepatocyte monolayer culture and rats were used as in vitro and in vivo hepatoprotective screening models also very useful. In the in vitro studies, different extracts and fraction we can screened. Silymarin can be used as reference drug. In the in vivo studies, hepatotoxicity was induced in wistar rats species give satisfactory results as per reported methods and administering a mixture of CCl4: olive oil (1:1, 2 ml/kg, s.c.) can be used for the inducible purpose. The extent of hepatotoxicity can be assessed by measuring the serum enzyme levels. So overall parameters consider for the CCl4 induced hapatoxicity in rats.

Keywords: Antioxidant; Carbon tetrachloride; Chenopodium album; Hepatoprotective


Download data is not yet available.

Author Biographies

Himanshu Jain

Department of Pharmacology, Jaipur College of Pharmacy, Jaipur

Yogesh Kumar Sharma

Department of Pharmacology, Jaipur College of Pharmacy, Jaipur


1. Asolkar LV, Kakkar KK, Chakre OJ. Glossary of Indian Medicinal Plants with active principles, 1 st part, NISCAIR, New Delhi, India, pp 195-196, 1992.
2. Kirtikar KR, Basu BD. Indian Medicinal Plants, 2 nd edition, International Book Distributors, Dehradun, India, pp 2071- 2072, 2005.
3. Raju M, Varakumar S, Lakshminarayana R, Krishnakantha TP, Baskaran V. Carotenoid composition and vitamin A activity of medicinally important green leafy vegetables. Food Chem 2007; 101:1621-8.
4. Zlatina KN, Paraskev TN, Stefan DN. The genus Chenopodium: phytochemistry, ethnopharmacology and pharmacology. Pharmacog Rev 2009; 3:280-306.
5. Gohar AA, Elmazar MMA. Isolation of hypotensive flavonoids from Chenopodium species growing in Egypt. Phytother Res 1997; 11:564-7.
6. Dai Y, Ye WC, Wang ZT, Matsuda H, Kubo M, But PP. Antipruritic and antinociceptive effects of Chenopodium album L. in mice. J Ethnopharmacol 2002; 81:245-50.
7. Jabbar A, Zamana MA, Iqbal Z, Yaseen M, Shamim A. Anthemintic activity of Chenopodium album (L.) and Caesalpinia crista (L.) against trichostrongylid nematodes of sheep. J Ethnopharmacol 2007; 114:86-91.
8. Khoobchandani M, Ojeswi BK, Sharma B, Srivastava M. Chenopodium album prevents progression of cell growth and enhances cell toxicity in human breast cancer cell lines. Oxid Med Cell Longe 2009; 2:160-5.
9. Nigam V, Paarakh PM. Hepatoprotective activity of Chenopodium album Linn. against paracetamol induced liver damage. Pharmacologyonline 2011; 3:312-28.
10. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. Nirali Prakashan Publication, Pune, India, pp 109-137, 2005.
11. Jain NK, Singhai AK. Protective effects of Phyllanthus acidus (L.) Skeels leaf extracts on acetaminophen and thioacetamide induced hepatic injuries in Wistar rats. Asian Pac J Trop Med 2011; 4:470-4.
12. Jain NK, Lodhi S, Jain A, Nahata A, Singhai AK. Protective effects of Phyllanthus acidus (L.) Skeels extract on acetaminophen mediated hepatic injury and oxidative stress in Wistar rats. J Compl Integra Med 2010; 7. DOI: 10.2202/1553-3840.1439.
13. Robak J, Gryglewski RJ. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 1998; 37:837-41.
14. Jain NK, Singhai AK. Ameliorative effects of Spinacia oleracea L. seeds on carbon tetrachloride (CCl4) - induced hepatotoxicity: In vitro and in vivo studies. Asian Pac J Trop Biomed 2012; 1:S232-7.
15. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28:53-6.
135 Views | 146 Downloads
How to Cite
Jain H, Sharma YK. A Review on Study of Hepatoprotective Activity of Chenopodium Album Linnon CCl4 Induced Hepatotoxicity in Rats. JDDT [Internet]. 30Aug.2019 [cited 18Aug.2022];9(4-A):790-2. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3614