Formulation and Evaluation of Floating Microspheres of 1,1-Dimethylbiguanide

  • Saurabh Sharma
  • Yogesh Matta
  • Sandeep Singh
  • Kajol Rustage
  • Ashwani Kumar
  • Neha Arora

Abstract

1,1-Dimethylbiguanide is a hypoglycemic agent used in the treatment of non-insulin dependent Diabetes mellitus. It is a BCS Class –III drug having poor permeability. Plasma half life ranges from 1.5-3 hrs & oral bioavailability is 50-60%. Hence require frequent oral administration for adequate treatment of Diabetes in order to extend the gastric retention time oral sustained dosage form was developed in the form of microspheres using polymers (sodium CMC, HPMC K 100 M). The results presented that drug dissolution rate and drug entrapment increases while decreasing the polymer amount. All the formulations are evaluated for dissolution, entrapment efficiency, percentage buoyancy and 1,1-Dimethylbiguanide Microspheres of formulations, F-4 was found to be optimized formulation based on in-vitro release pattern and percentage buoyancy entrapment efficiency.


Keywords: 1,1-Dimethylbiguanide, half-life formulations, efficiency.

Downloads

Download data is not yet available.
Statistics
32 Views | 39 Downloads
How to Cite
1.
Sharma S, Matta Y, Singh S, Rustage K, Kumar A, Arora N. Formulation and Evaluation of Floating Microspheres of 1,1-Dimethylbiguanide. JDDT [Internet]. 30Aug.2019 [cited 24Oct.2020];9(4-A):742-7. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3594

Most read articles by the same author(s)