Pharmacognostic, Phytochemical and Hepatoprotective Activity of the Leaves of Mirabilis jalap

  • A. Singh Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Sam Higginbottom University of Agricultural Sciences and Technology, Naini, Allahabad, UP, India.
  • V. Kumar Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Sam Higginbottom University of Agricultural Sciences and Technology, Naini, Allahabad, UP, India.
  • A. Rajendiran University Institute of Pharmacy, C.S.J.M.U. Kanpur, India
  • N. Agnihotri University Institute of Pharmacy, C.S.J.M.U. Kanpur, India

Abstract

Recent regular research on medicinal plants is producing remarkable and significant results. Thus, there is lot of scope to find new outcomes from plants like Mirabilis jalapa - a plant which need more investigation in the area of medicine and medical science. The present study deals with the establishment of organoleptic microscopic and phytochemical profiling of Mirabilis jalapa leaves, along with hepatoprotective activity on leaf extract against CCL4. The total phenolic content was found to be 1.36 ± 0. 02 mg/gm of dried leaf extract equivalent to Gallic acid and flavonoids content of the extract was found to be 4.41± 0.02 mg/gm. The successively extracted extract showed the IC50 value against the DPPH free radical. Methanolic extract of leaves shows very significant hepatoprotective activity at 200mg & 400mg when compared with standard. Based on the result, the pharmacognostic profiling of the Mirabilis jalapa leaves was successfully established. Present finding also suggested that it could be a source of potent antioxidant drugs as leves leaves are also hepatoprotective in nature.


Keywords: Mirabilis jalapa, Nyctaginaceae, phenolic content, flavonoids content, Antioxidant.

Keywords: Mirabilis jalapa, Nyctaginaceae, phenolic content, flavonoids content, Antioxidant

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Author Biographies

A. Singh, Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Sam Higginbottom University of Agricultural Sciences and Technology, Naini, Allahabad, UP, India.

Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Sam Higginbottom University of Agricultural Sciences and Technology, Naini, Allahabad, UP, India.

V. Kumar, Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Sam Higginbottom University of Agricultural Sciences and Technology, Naini, Allahabad, UP, India.

Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Sam Higginbottom University of Agricultural Sciences and Technology, Naini, Allahabad, UP, India.

A. Rajendiran, University Institute of Pharmacy, C.S.J.M.U. Kanpur, India

University Institute of Pharmacy, C.S.J.M.U. Kanpur, India

N. Agnihotri, University Institute of Pharmacy, C.S.J.M.U. Kanpur, India

University Institute of Pharmacy, C.S.J.M.U. Kanpur, India

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Singh A, Kumar V, Rajendiran A, Agnihotri N. Pharmacognostic, Phytochemical and Hepatoprotective Activity of the Leaves of Mirabilis jalap. JDDT [Internet]. 30Jul.2019 [cited 29Nov.2021];9(4):799-05. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3575