CONTRACEPTIVE VAGINAL SUPPOSITORY CONTAINING nONOXYNOL-9 AND ZINC ACETATE SALT IN A CLINICAL TRIAL
Nonoxynol-9 (N-9) is the most common active ingredient of spermicides. Spermicides containing N-9 are available in many forms, such as jelly, films, suppositories and foams. The two major problems reported on using N-9 spermicide were high failure and high irritation rates which were the main causes of its withdrawing from markets and as we know local methods of contraception (condoms and vaginal suppositories) have high acceptability especial in short term use. We tried to modify N-9 products in a new formula which is safe, and effective. The new preparation based on the addition of low concentrations of zinc acetate salt (Zn (OAC)2) to N-9 that reduce the irritation of mucous membranes on frequent use and increase the efficacy of N-9. The new preparation made in the form of vaginal foaming suppository.Â It was tested in-vitro and in-vivo. The in-vitro results show a significant increase in efficacy of the combination (Zn (OAC)2 & N-9) than N-9 alone. Additionally, the in-vivo results indicated a significant decrease in failure and irritation rates in the combination than (N-9 alone) market suppository.
Key words: Contraceptive, Nonoxynol-9, Zinc acetate, irritation and efficacy
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).