Preformulation Studies of Rapid Dissolving Films Containing Granisetron Hydrochloride
Rapid-dissolving solid drug dosage forms for application onto the oral cavity for the pediatric population seem to be very appropriate, especially in preterm and term infants. The delivery of drugs via the oral mucosa offers easy application, prevents drug degradation by gastrointestinal fluids, avoids first-pass metabolism and potentially improves bioavailability. Granisetron hydrochloride (GSH) drug is used as antiemetic agent. Proposed work comprise of preformulation studies of Granisetron hydrochloride. For that, physicochemical parameters were determined; like melting point of GSH was determined using melting point apparatus, Granisetron hydrochloride was scanned in the distilled water, Acid buffer, pH 1.2 and Phosphate buffer, pH 6.8. The IR spectrum of pure drug (GSH), Pullulan, METHO K3P, METHO E3P, METHO E15P and POLYOX WSR N10 were recorded in potassium bromide using Shimadzu FTIR – 8400S(CE). Solubility of Granisetron hydrochloride was determined using shake flask method. Standard Plot of Granisetron hydrochloride in distilled water, Acid buffer, pH 1.2 and Phosphate buffer, pH 6.8 were taken, all the parameter obtained were satisfactory, which will be used further for formulation of rapid dissolving film.
Keywords: Rapid dissolving film, Granisetron hydrochloride (GSH), Preformulation.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).