Bioavailability Enhancement of Curcumin via Mucoadhesive Drug Delivery System
Abstract
The main aim of this study was to improve the bioavailability of curcumin through buccal route using mucoadhesive drug delivery. Curcumin is practically insoluble in water. After oral administration, most part of the drug was metabolism in liver .Therefore an attempt has been made to improve the bioavailability by using different concentration of sodium lauryl sulphate as bioenhancer. Buccal bilayer tablets were prepared by direct compression with different ratio of HPMC.K4M.as bioadhesive polymer and ethyl cellulose as backing layer. The formulation were characterized for various physiochehimical parameter such as weight variation, thickness, hardness, fribality, mucoadhisive strength, drug content, swelling studies and in vitro diffusion studies. The best mucoadhesive performance and In vitro drug release profile exhibited by tablets containing hydroxyproply methylcellulose K4M (5%) and Sodium louryl sulphate (0.1%).To conclude that the formulated unidirectional, bilayered, buccoadhesive tablet for curcumin using HPMC as mucoadhesive agent is superior to oral conventional tablet, as it has the potential to bypass the first pass metabolism and improve the bioavailability of curcumin.
Keywords: Curcumin, Ethyl cellulose, Sodium Lauryl Sulphate, HPMC.
Downloads
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).