Effect of Cross Linking on Evaluation of Chitosan Coated Pellets of Glipizide
The objective of the current work is to develop and evaluate the effect of cross linking on drug release of chitosan pellets of Glipizide. Hence the present work was aimed to formulate glipizide pellets with a view to achieve and to maintain the plasma concentration for considerable period by controlling the release so to decrease the occurrence of doses and also to recover the patient fulfillment. Here the pellets of glipizide are designed by Pan Coating technique with solution layering with and without cross linking by Gluteraldehyde effectively. Then the optimized formulations are aimed to study the effects of polymer and cross linking on different evaluation parameters including the drug release study. Finally the conclusion was to arrive at better formulation based on comparison amongst the studied ones.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).