Synthesis and Anxiolytic Activity of some novel benzotriazole derivatives

  • V. K. Singh
  • Peeyush Bharadwaj
  • Poonam Rishishwar


1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. It is a polar and colourless compound which can be used for its great versatility. The enormous investigations on derivatives of benzotriazole reveal wide applicability for tagging and delivering a number of heterocyclic nuclei with this molecule. In the present work synthesis of several derivatives of 2-(substituted)-5-[(N-benzotriazolomethyl)-1,3, 4-thiadiazolyl]- imidazole-2-thione has been synthesized and are evaluated for their anxiolytic activity. The antianxiety activities of the synthesized derivatives were evaluated using EPM test and Bright and dark box test experimental models of anxiety. All results were expressed as mean± standard error mean (SEM) and analysed by one-way ANOVA. Post-hoc comparisons were performed by applying Dunnet’s test. P <0.05 was considered statistically significant.

Keywords: Benzotriazole; Thiadiazole; Thiazolidinone; Anxiolytic Activity; Anxiety; Elevated Plus Maize; Bright and Dark Arena.


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Author Biographies

V. K. Singh

School of Pharmacy, Monad University, Panchsheel Nagar, Hapur (U.P.)

Peeyush Bharadwaj

Institute of Pharmacy, Bundelkhand University, Jhansi (UP), India

Poonam Rishishwar

Arunachal University of Studies, Namsai, Arunachal Pradesh, India

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How to Cite
Singh VK, Bharadwaj P, Rishishwar P. Synthesis and Anxiolytic Activity of some novel benzotriazole derivatives. JDDT [Internet]. 30Aug.2019 [cited 29Oct.2020];9(4-A):98-03. Available from: