HYPOGLYCAEMIC EFFECT OF SAPONIN FROM THE ROOT OF GARCINIA KOLA (BITTER KOLA) ON ALLOXAN-INDUCED DIABETIC RATS
Garcinia kola Heckel is a species of flowering plant in the Guttiferae family. The plant has been reffered to as a â€˜wonder plantâ€™ because every part of it has been found to be of medicinal importance.Â In this present study, saponin extract from the root of Garcinia kola was evaluated for antidiabetic activity in Wistar albino rats. Diabetes was induced in rats byÂ single intraperitonial injection of alloxan(150mg/kg body weight). Three days afterÂ alloxan induction, the hyperglycemic rats were treated withÂ metformin, a standard antidiabetic drug and saponin from the root of Garcinia kola orally at the dose of 100, 200 and 400 mg/kg body weight daily for 7 days. The fasting blood glucose levels were measured on the 3rd and 7th day during the 7 days treatment. Serum biochemical parameters such asÂ Â Alanine Transaminase (ALT), Aspartate Transaminase (AST), Â Alkaline Phosphatase (ALP), and total protein were estimated. The saponin extract at the dose of 100mg/kg produced the maximum reduction of 35.98% in blood glucose after the 3rd day treatment as compared to the 31.26% observed for metformin. 200mg/kg dose of saponin produced a maximum reduction of about 72.67% after the 7th day treatment as compared to 35.84% observed for metformin. The present study infers that saponin extract from the root of Garcinia kola demonstrated remarkable antidiabetic activity even more than a standard antidiabetic drug in alloxan-induced diabetic rats. Consequently, this plant may be of value in diabetes treatment.
Key words: Antidiabetic, Saponin, Garcinia kola, Alloxan.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).