SELF DOUBLE EMULSIFYING DRUG DELIVERY SYSTEM (SDEDDS): A REVIEW
Self emulsifying drug delivery systems (SEDDS) are well known for its potential to improve the aqueous solubility and oral absorption of lipophilic drugs. Self double-emulsifying drug delivery system (SDEDDS) are basically used for drugs having low solubility in water, but its potential application for the drugs defined as â€œhigh solubility low permeability classâ€ or a biopharmaceutical classification system [BCS] class III drug is appreciable, in which gastrointestinal permeation is the rate controlling step in the absorption process. The most important factor affecting the oral absorption of a drug, besides dissolution, is the permeability of the drug across the gastrointestinal lining. Improving permeability may, therefore, potentially improve the bioavailability of a drug. In this review we discuss the preparation, stability, formulation and characterization of SDEDDS.
Key Words: Multiple emulsion, self emulsifying, Protein peptide drug delivery, High soluble poorly permeable drugs.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).