Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents

  • Nalini Patel
  • Vaishali Karkhanis
  • Pinkal Patel

Abstract

Some 1-((4-methylpiperazin-1yl)methyl)-1H-benzo[d]imidazole & 1-((4-phenylpiperazin-1yl)methyl)-1H-benzo[d]imidazole derivatives were synthesized through reaction of 1-substituted piperazines with different benzimidazole derivatives in methanol yielded the corresponding mannich bases (42-a to 42-i). All the synthesized compounds were elucidated by IR, 1H NMR and MASS spectroscopy. They were tested for anti-inflammatory activity using in-vivo (Carrageenan- induced rat paw edema model) method at a dose of 50mg/kg. result showed that compounds 42-c, 42-d and 42-h were found to be most potent in series.


Keywords: 1,4-disubstituted Piperazine, Anti-inflammatory, Mannich Base.

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Patel N, Karkhanis V, Patel P. Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents. JDDT [Internet]. 15Aug.2019 [cited 20Apr.2021];9(4-s):353-8. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3327