A Research Article Phytochemical and Pharmacological Evaluation of Carthamus tinctorius Leaves

  • Rahul Pant Department of Pharmacy, Bundelkhand University Jhansi, U.P.
  • Raghuveer Irchhaiya
  • Ch. V. Rao

Abstract

Hepatoprotective activity of methanolic extract of leaves of Carthmus tinctorius L. (MECT) was investigated against hepatotoxicity produced by administering a combination of two anti-tubercular drugs Isoniazid and Rifampicin for 24 days by Oral route in rats. MECT were administered at two graded dose i.e. 200 and 300 mg/kg p.o. 45 min after to anti-tubercular challenge for 24 days. MECT was evident in the all doses as there was a significant decrease in AST, ALT, ALP, and Total Bilirubin levels. MECT significantly decreased the level of these biochemical parameter as compared to control. HPTLC analysis showed the presence of B-sitosterol and Lupeol in MECT. Results showed that Carthamus tinctorius possess significant Hepatoprotective activity which might be due to flavonoids.


Keywords: Carthamus tinctorius leaves1, hepatoprotective2, Rifampicin3, Isoniazide4, SGPT5.

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Author Biographies

Raghuveer Irchhaiya

Department of Pharmacy, Bundelkhand University, Jhansi, U.P.

Ch. V. Rao

Pharmacognosy and Ethnopharmacology Division, N.B.R.I. Lucknow, U.P.

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1.
Pant R, Irchhaiya R, Rao CV. A Research Article Phytochemical and Pharmacological Evaluation of Carthamus tinctorius Leaves. JDDT [Internet]. 15Aug.2019 [cited 29Nov.2021];9(4-s):285-94. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3277