DEMONSTRATION OF LYMPHATIC UPTAKE OF (6)-GINGEROL SOLID LIPID NANOPARTICLES

  • Mangesh R Bhalekar
  • Ashwini Madgulkar
  • Tejaswini Vikram Jagtap AISSMS College of pharmacy
DOI https://doi.org/10.22270/jddt.v9i4.3193

Abstract

(6)-Gingerol, a disease modifying anti-rheumatoid drug (DMARD) agent in the treatment of Rheumatoid Arthritis is a potent inhibitor of COX-1, COX-2 activity, inhibits PGE2 production. It also inhibits the production of TNF-α by blocking the cell associated conversion of TNF precursor to mature proteins thus, halting the proliferation of synovitis. (6)-Gingerol undergo extensive phase I metabolism & underlies low systemic exposure. The aim of the present study was to overcome these limitations and formulate and evaluate Ginger extract Solid Lipid Nanoparticles to improve bioavailability by enabling lymphatic uptake. (6)-Gingerol Solid Lipid Nanoparticles were prepared by melt emulsification-homogenization method and the particle size, Zeta potential PDI and % entrapment efficiency was optimized using Box Behnken design. The optimized SLN were found to be 237nm in size, bearing -25.3mv zeta potential, 0.350 PDI and entrapment efficiency of 91.33%.  Ex vivo endocytic uptake studies (everted intestine method) revealed involvement of endocytic pathways in the uptake of Solid Lipid Nanoparticles from intestine. Thus underlining the utility of SLN for enhancement of uptake of (6)-Gingerol.

Downloads

Download data is not yet available.

Author Biographies

Mangesh R Bhalekar

1,2,3Department of pharmaceutics, AISSMS College of Pharmacy, Savitribai Phule Pune University, Pune, India-411001

Ashwini Madgulkar

1,2,3Department of pharmaceutics, AISSMS College of Pharmacy, Savitribai Phule Pune University, Pune, India-411001

Statistics
142 Views | 177 Downloads
How to Cite
1.
Bhalekar MR, Madgulkar A, Jagtap T. DEMONSTRATION OF LYMPHATIC UPTAKE OF (6)-GINGEROL SOLID LIPID NANOPARTICLES. JDDT [Internet]. 15Jul.2019 [cited 3Mar.2021];9(4):461-9. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3193
Issue
Vol 9 No 4 (2019): Volume 9, Issue 4, July-August 2019
Section
Research
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).