Sense and response in the cell
Almost a century ago, Paul Ehlrich proposed the concept of the ‘receptors’ as sensing components of cellular signaling pathways for the mediation of downstream response in context of toxin action. Since then, we have come a long way in describing the signal transduction through dynamic sense & response in various domains of cell physiology studies, beyond the static ‘receptor-ligand’ mechanism. A multi-nodal characteristic of such signaling modules generates an enriched version of temporal signals responsible for a fine-tuned cellular response based on the identity and severity of stimulus. Here, we review diverse modes of dynamic signal transduction mechanism for efficient cellular response.
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