Nanoparticulates of Fenofibrate for Solubility Enhancement: Ex-Vivo Evaluation
Abstract
The aim of present research work was to formulate and evaluate nanosuspension of fenofibrate which is categorized as BCS class II agent. With an intention to increase solubility and dissolution rate of fenofibrate nanosuspension were prepared by high pressure homogenization method, a top down technique. Using poloxamer 188 and Tween 80 as a stabilizer. Formulation scheme was developed by Box Behnken Design. Formulation factor which affect the particle size includes Concentration of surfactant and processing parameters includes Homogenization pressure and Homogenization cycles. In this study practically water insoluble fenofibrate was nanosized and surfactant was added for their stabilizing effect. In vitro dissolution study showed that the increase in the release rate of fenofibrate from nanoparticles as compared to pure drug. Scanning electron microscopy study showed that the spherical morphology of nanoparticles. Particle size distribution, zeta potential, crystal form of formulated nanosuspension were studied by using particle size analyzer, and X-ray powder diffraction, Ex-vivo study for calculating absorption rate. The result showed that the drug dissolution rate in nanosuspension formulation is depends upon the crystal form, solubility, procedure involved, and stabilizer used.
Keywords: Solubility, Dissolution, high pressure homogenization, lyophilization, nanosuspension.
Downloads
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.