Analgesic Activity of Hydroalcoholic Leave Extract of the Putranjiva roxburghii.
Background: this study was aimed to assess the possible analgesic activity of Putranjiva Roxburghii in albino’s Wister rats.
Method: Rats were divided in 5 groups of 6 animal each, I group served as control, II group as standard (Pentazocin) while group III, IV and V were treated with leaves extract of Putranjiva Roxburghii at doses of 20,100,200 and 400 mg/kg respectively. The statistical analysis of results were carried out using and one way (ANOVA) followed by students t-test.
Result and Discussion: the analgesic activity was determined based on the reaction time. The effect of the hydroalcoholic leaves extract of Putranjiva Roxburghii and references also evaluated. The hydroalcoholic leaves extract of Putranjiva Roxburghii administered orally the four different doses produced significant analgesic activity and reduced Pentazocin induced reaction time (analgesic effect) in dose dependent manner. The effect of 400 mg/kg (p.o.) having better activity than 100 and 200 mg/kg was similar to that of reference drug Pentazocin (5 mg/kg, p.o.).
Conclusion: the results showed that hydroalcoholic leave extract of Putranjiva Roxburghii has a 400 mg/kg act as significant for analgesic activity.
Keywords: Analgesic, Pentazocin, reaction time.
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