BURDEN OF MIGRAINE
Migraine is a chronic neurological disorder with several trigger factors including dietary, hormonal and environmental factors. Migraine is a Primary headache disorder characterized by recurrent headaches that are moderate to severe. Typically, the headaches affect one-half of the head, are pulsating in nature, and last from two to 72 hours. Nitrates, such as cardiac therapeutics and food additives, are common headache triggers, with nitric oxide playing an important role. Trigger factors are frequent in migraine patients, it avoidance may decrease headache frequency and also improve patients quality of life. Facultative anaerobic bacteria in the oral cavity may contribute migraine-triggering levels of nitric oxide through the salivary nitrate-nitrite-nitric oxide pathway.
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