Synthesis and Evaluation of Aldehyde Derivatives of Sulfonyl Chloride Quinoxaline

  • Rakesh Goyal Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Mukesh Sharma Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Dharmendra Ahuja Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Anurekha Jain Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Abstract

In pyrazine mesomeric interaction between the protonated & neutral nitrogen atoms probably destabilizes the cation.N, N’-diprotonation is very easier for pyrazine Synthesis of 2, 3-diphenylquinoxaline by phenylene-diamine in 16 ml of rectified spirit was added & combine solution was warm in water bath for 30 min. added water until slight colorless persist & allow to cool recrystallize the product in ethanol.   Synthesis of 2, 3-diphenylquinoxaline 7-sulfonylchloride (R) using chlorosulfonic acid under ice-cold condition, then Synthesis of  2-hydroxyphenyl-2,3-diphenylquinoxaline-7-sulphonate(R1) throughresorcinol with 3ml pyridine & sulphonyl chloride derivative, Synthesis of 2-formylphenyl-2,3-diphenylquinoxaline-7-sulphonate(R7)obtained by reaction of salicylaldehyde with pyridine & sulphonyl chloride derivative then Synthesis of 3-formylphenyl-2,3-diphenylquinoxaline-7-sulphonate(R9) obtained by heating on water bath mixture of3-hydroxybenzaldehyde with pyridine & sulphonyl chloride, Synthesized quinoxaline derivatives were subjected to antimicrobial susceptibility testing by well diffusion method against gram positive (S.aureus, 2079) and gram negative bacteria (E. coli, 2685). The results of quinoxaline derivatives in terms of zone of inhibition recorded. MIC of quinoxaline derivative was determined by tube micro dilution technique against S. aureus and E. coli. The turbidity was measured by UV at about 420 nm. Hydrogen peroxide scavenging activity and 1, 1 diphenyl 2, picryl hydrazyl Method (DPPH) calculated and Most of the derivatives have shown comparable antioxidant activity in relation to standard Ascorbic acid and DPPH. 

Keywords: QSAR, Sulfonyl Chloride Quinoxaline, Ant-microbial, Antioxidant

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Author Biographies

Rakesh Goyal, Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Mukesh Sharma, Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Dharmendra Ahuja, Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Anurekha Jain, Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

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Goyal R, Sharma M, Ahuja D, Jain A. Synthesis and Evaluation of Aldehyde Derivatives of Sulfonyl Chloride Quinoxaline. JDDT [Internet]. 30Aug.2019 [cited 24Oct.2020];9(4-A):921-7. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3142