The shelf life study of 0.1 M Sodium hydroxide volumetric solution at different condition for analytical purpose in Laboratory

  • Sunil Kumar
  • Bigan Ram

Abstract

The  Expiry  date  of  0.1 M    Sodium hydroxide  volumetric  solution   is  determined  for  analytical  purpose  in  Laboratory  and  the  Strength  of  Volumetric  solutions   determined  by  titration  against  potassium   hydrogen   Phthalate (KHP).   The   volumetric  solution  prepared  in   distilled   water observed   that   no  chemically  significant   degradation   for  at  least  30  days   when   stored  separately  in   Normal  and  dark  condition  over   a period  of 30  days . The %  RSD  of  Molarity  at Normal  condition  observed  from  0.0993  to  0.0994 %  and   at  Dark condition    from  0.0994  to 0.2988 %.  The  Significant  degradation    observed   when   solution  stored   separately  in  oven  at  35 oC   temperature   and  strength   of   volumetric   solution   deviate   from   18 th   Day . The Degradation of  solution  strength   found  to  0. 98 %  after storage  for 30 days  at  35 oC  Temperature.


Keywords:  Shelf life, Stability, Titrimetric, Primary standard, Hold time study, Degradation.

Downloads

Download data is not yet available.

Author Biographies

Sunil Kumar

Department of chemistry, K.S. College (L.N. Mithila University) Darbhanga-846003, Bihar, India

Bigan Ram

Department of chemistry, Women's  College (L.N. Mithila University) Samastipur-848101,Bihar, India.

References

(1) Indian Pharmacopoeia 2007, Volume 1; Volumetric Reagents and Solutions : p.316.
(2) United states Pharmacopoeia 35, NF-30;Test Solutions / Solutions: p.5334.
(3) J.M.F.Nogueira, P.Serodio. Determination of the expiration date of Chemical solutions, Accreditation and Quality Assurance.2003;8(5) :p.231-234.
(4) B.A. Bruer, D.R.G Bruer, C.J.Brien. Shelf life of some common winery laboratory reagents. Am J Enol Vitic.1982; 33(3):p.159-163.
(5) World Health Organization ,WHO Technical Report Series, No. 957, Annex 1, WHO good practices for pharmaceutical quality control laboratories; 2010:p.102-103.
(6) ICH, Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients Guidance for Industry, Laboratory Control Records; September 2016: p.18-19.
Statistics
1819 Views | 531 Downloads
How to Cite
1.
Kumar S, Ram B. The shelf life study of 0.1 M Sodium hydroxide volumetric solution at different condition for analytical purpose in Laboratory. JDDT [Internet]. 23Oct.2019 [cited 29Nov.2021];9(4-s):957-60. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3139