Formulation and In-Vitro Evaluation of Metformin Hydrochloride Sustained Release Tablets

  • Chinna Eswaraiah Maram Anurag Pharmacy College
  • Jaya Sollu Anurag Pharmacy College


The objective of the present study was to study the effect of hydrophilic polymers on sustained release of metformin hydrochloride from tablets. Compatibility was studied by Fourier transform infrared spectroscopy. The tablets were prepared by direct compression technique using Xanthan gum alone and in combination with HPMC as release retardant. Di calcium phosphate was used as diluent. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity and in-vitro dissolution. Pre and post compression parameters were evaluated and all the parameters were found within the limit. The drug release data were subjected to different models in order to evaluate release kinetics and mechanism of drug release. Formulation F5 was selected as best formulation. The dissolution of formulation F5 can be described by first order kinetics with fickian diffusion as the release mechanism.

Keywords: Matrix tablets, Metformin hydrochloride, Xanthan gum, HPMCK4M and HPMCK15M.


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1. Amitava R, Kalpana R, Sarbani R, Jyotirmoy D, Amitava G and Kazi AA. Response surface optimization of sustained release metformin hydrochloride matrix tablets: Influence of some hydrophilic polymers on the release. Int Scholar Res 2012
2. Zubin P, Ronald G and Pamela K. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Canadian J Diabetes 2018; 42 (Suppl-1): S10-S15.
3. Jphn R, Cesar G, Carolina R and Oswald S. Formulation of modified release metformin hydrochloride matrix tablets: Influence of some hydrophilic polymers on release rate and invitro evaluation. Brazilian J of Pharm Sci 2011; 47(3): 483-93.
4. Rohini D, Alexander S and Chandrasekar MJN. Preparation and in-vitro evaluation of sustained release tablet formulations of metformin HCL. Asian J Pharm and Clinical Res 2012; 5(1): 45-8.
5. Sunil R, Pavan KP, Rajanarayana K and Madhusudan RY. Formulation and release characteristics of a bilayer matrix tablets containing glimepiride immediate release component and metformin hydrochloride as sustained release component. Int J Pharma Sci Nano Tech 2010; 3(1): 851-9.
6. Basavaraj KN, Sunil RM and Manvi FV. Formulation of extended-release metformin hydrochloride matrix tablets. Trop J Pharma Res 2011; 10 (4): 375-83
7. Harekrishna Roy, Chandan KB, Sisir n and Kirti RP. Formulation and design of sustained release matrix tablets of metformin hydrochloride: Influence of hypromellose and polyacrylate polymers. Int J Appl Basic Med Res 2013; 3(1): 55-63.
8. Karvekar m and Arshad BK. A brief review on sustained release matrix type drug delivery system. J Pharma Res 2017; 16(3): 282-9.
9. Jaya S and Srilaxmi G Formulation and in-vitro characterization of ambroxol hydrochloride sustained release matrix tablets. Int J Pharma Sci and Res 2019; 10(3): 1208-13.
10. Chinna Eswaraiah M and Jaya S. formulation and evaluation of floating matrix tablets of metronidazole. Asian J Pharma Clini Res 2019; 12(3): 539-544.
11. Atif A, Iqbal M, Naveed A, Haji MSK, Aftab U, Minahaj U and Tahir MK. Assessment of xanthan gum based sustained release matrix tablets containing highly water soluble propranolol HCL. Acta Poloniac Pharm Drug Res 2013; 70: 283-9.
12. Jaya S and Amala V. Formulation and invitro evaluation of oral disintegrating tablets of amlodipine besylate. Int J Appli Pharmac 2019; 11(1):49-54.
13. Sudipta D, Arnab S, Himadri SD. Formulation, in-vitro release kinetics and stability interpretation of sustained release tablets of metformin hydrochloride. Int J Pharma Pharma Sci 2015; 7(3):418-22.
14. Jaya S and Divya S. Formulation and in-vitro evaluation of matrix tablets of metoclopramide hydrochloride. Int J Appli Pharma 2019; 11(2):25-30.
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How to Cite
Maram C, Sollu J. Formulation and In-Vitro Evaluation of Metformin Hydrochloride Sustained Release Tablets. JDDT [Internet]. 2Jul.2019 [cited 9Mar.2021];9(4):24-9. Available from: