Formulation Development and Evaluation of Diacerein Loaded Microsphere by Spray Coating (Wurster Method)
Diacerein loaded microspheres were prepared by spray coating(wurster method) using hydroxyl propyl methyl cellulose (HPMC) and ethyl cellulose as release retarding polymer with a view to manufacture sustained release drug delivery. Drug content in the microspheres was determined by HPLC assay followed by drug entrapment efficiency. Shape and Surface topography of Diacerein loaded microspheres was determined by scanning electron microscopy. Fourier transform infrared spectroscopy (.FT-IR), X-ray diffraction Spectroscopy (XRD), and Differential scanning calorimetry (DSC) studies were done to establish drug polymer and other excipients compatibility and stability. Sustained release action was established by In-vitro release study. The result shows that Diacerein loaded microsphere using hydroxyl propyl methyl cellulose and ethyl cellulose polymer can be a new addition in the field of pain management for the treatment of osteoarthritis.
Keywords: Microsphere, Diacerein, HPMC, Ethyl cellulose, Spray coating.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).