Formulation Development and Evaluation of Diacerein Loaded Microsphere by Spray Coating (Wurster Method)

  • Soumen Mukhopadhyay
  • Tathagata Roy
  • Tapan Kumar Chatterjee
DOI https://doi.org/10.22270/jddt.v9i4.3082

Abstract

Diacerein loaded microspheres were prepared by spray coating(wurster method) using hydroxyl propyl methyl cellulose (HPMC) and ethyl cellulose as release retarding polymer with a view to manufacture sustained release drug delivery. Drug content in the microspheres was determined by HPLC assay followed by drug entrapment efficiency.  Shape and Surface topography of Diacerein loaded microspheres was determined by scanning electron microscopy. Fourier transform infrared spectroscopy (.FT-IR), X-ray diffraction Spectroscopy (XRD), and Differential scanning calorimetry (DSC) studies were done to establish drug polymer and other excipients compatibility and stability. Sustained release action was established by In-vitro release study. The result shows that Diacerein loaded microsphere using hydroxyl propyl methyl cellulose and ethyl cellulose polymer can be a new addition in the field of pain management for the treatment of osteoarthritis.  


Keywords: Microsphere, Diacerein, HPMC, Ethyl cellulose, Spray coating.

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Author Biographies

Soumen Mukhopadhyay

Division of pharmacology, Department of pharmaceutical Technology, Jadavpur University, Kolkata 700032

Tathagata Roy

Depertment of pharmaceutical technology, JIS University, Kolkata 700109

Tapan Kumar Chatterjee

Depertment of pharmaceutical technology, JIS University, Kolkata 700109

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How to Cite
1.
Mukhopadhyay S, Roy T, Chatterjee TK. Formulation Development and Evaluation of Diacerein Loaded Microsphere by Spray Coating (Wurster Method). JDDT [Internet]. 15Jul.2019 [cited 7Dec.2021];9(4):454-60. Available from: http://www.jddtonline.info/index.php/jddt/article/view/3082
Issue
Vol 9 No 4 (2019): Volume 9, Issue 4, July-August 2019
Section
Research
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