Formulation Development and Evaluation of Gastroretentive Delivery System (Microspheres) Using Natural Polymer
Microspheres are novel drug delivery approach to control release of pharmacologically active ingredient as per patient need. Natural polymers like fenugreek mucilage are cheap, biodegradable and have been proved safe for pharmaceutical formulation. Higher loading efficiency was observed for all the formulations and also the drug release was observed for the period of 12 hours. Thus, the simvastatin microsphere using fenugreek mucilage showed promising results in retarding the drug release. It can be concluded from whole study that due to the formation of polymeric network system or other active moiety can be easily entrapped with the matrix and hydration and swelling of natural polymer controlled their release pattern
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