A Review: Formulation and Optimization of Sustained Release Eudragit Coated Metformin Hydrochloride
The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetic and pharmacodynamics properties of a drug in such a way that its utility is maximized, side-effects are reduced and cure of the disease is achieved. There are several advantages of sustained release (matrix) drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilisation of the drug, increased safety margin of potent drug, reduction in healthcare costs through improved therapy and shorter treatment period. Metformin hydrochloride is a biguanide antihyperglycemic agent which is a generally recommended first-line drug for the treatment of diabetes mellitus (Type II). When drug release is needed over a specific period of time or one would like to benefit from the advantages of multiparticulate or matrix formulations – Eudragit polymers can help to achieve desired release profile. Drug delivery can be controlled throughout the entire gastrointestinal tract to increase therapeutic effect and patient compliance.
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