A Review on Formulation and Evaluation of Gastroretentive Floating Tablet of Nifedipin
Different mass transport processes may occur during drug release from polymer-based matrix tablets, including water imbibition into the system, polymer swelling, drug dissolution, drug diffusion out of the tablet, and polymer dissolution. Depending on the type of drug, polymer and release medium and on the tablet composition, the respective processes are more or less important. Velasco et al.24 reported that the rate and mechanism of nifidipine release from HPMC K15M-based matrices were mainly controlled by the drug/ HPMC ratio, and that drug release was independent of the compression force in the range between 3 and 12 kN. The effects of the two formulation variables ‘‘HPMC/ lactose ratio’’ and ‘‘HPMC viscosity grade’’ on the release of adinazolam mesylate from cylindrical tablets was studied by Sung et al. The resulting drug release rate was found to increase with decreasing ‘‘HPMC/ lactose ratio’’ and decreasing ‘‘HPMC viscosity grade
Keywords: HPMC, Floating tablet, Gastroretentive, Gastric residence.
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