Design, Formulation and evaluation of sustained release tablet of divelproex sodium
In the present work, formulation and evaluation of Sustained tablet of Divalproex sodium was carried out. In the project, different formulations of sustained release layer have been prepared. From above formulations best formulation of each sustained release was selected according to the dissolution profile. Divalproex sodium is soluble in 0.1 N NaOH, phosphate buffer pH 6.8, chloroform, methanol, ethanol (95%), and sparingly soluble in water. The absorbance maximum of the Divalproex sodium was found to be at 210 nm when scanned in between 200-400 nm using methanol as well as phosphate buffer pH 6.8 solutions. All the characteristic peaks of Divalproex sodium were present in the spectrum of drug and excipient mixture, indicating compatibility between drug and excipients. In the present work SR tablets of Divalproex sodium were prepared by wet granulation method, using polymer like HPMC K4M for sustained release. Best formulations of was selected for Divalproex sodium were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction.
Keywords: Divalproex sodium, Sustained Release, HPMC and Epilepsy.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).