Formulation and Evaluation Transdermal Patch of Hesperidin
Abstract
The aim of the present study is to formulate and evaluate the transdermal patch of Hesperidin. In the present study, transdermal patch of Hesperidin were prepared by using HPMC E 5, Eudragit S 100 as a polymer, Dibutyl phthalate as a plasticizer and glycerin as a lubricant. Nine batches (F1-F9) were prepared by solvent evaporation method using methanol and chloroform in ratio 1:1 as a solvent. The prepared transdermal patches were evaluated on the basis of different parameters like weight, thickness, folding endurance, percent moisture content, drug content , in vitro drug release study. To confirm the optimised batch, the data were computed in design expert software. And it was concluded that the prepared formulation F5 batch showed highest percent of drug release.
Keywords: Transdermal drug delivery, Design expert, HPTLC, Hesperidin.
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