An efficient and facile synthesis of the hybrid scaffold of Pyrazole-Triazole-Chromenes nucleus using PS-TBD as a green catalyst
A series of 16 derivatives of pyrazole-triazole-chromene moieties (4a-p) were synthesized via one-pot cyclocondensation reaction of pyrazole-triazole aldehyde (1a-d), 1, 3 diketone (3a-d) and malononitrile (2a) in presence of PS-TBD as catalyst. The reusability of PS-TBD (polystyrene supported 7-methyl-1, 5, 7-triazabicyclo [4.4.0] dec-5-ene) catalyst makes this reaction quick and efficient. On the basis of various trials and its results, best performance and reusability of catalyst was observed at 5 mol% concentration. The reusability of catalyst founds up to 5 runs. A synthesized compound was characterized by 1HNMR, 13CNMR, FT-IR and C, H, N elemental analysis and confirms theoretical chemical reaction.
Keywords: Chromenes, Pyrazole, Triazole, PS-TBD catalysis Chemistry
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