Protective Activity of Tinospora cordifolia and Camellia sinensis extract on Alcohol-Induced Toxicity in Mice
Heavy alcohol intake depletes the plasma vitamins due to hepatotoxicity and decreased intestinal absorption. Medicinal plants may provide an effective remedy for the enormous health burden posed by alcohol abuse. This study was designed to observe the effects of alcohol on various hematological parameters in adult mice. A total of 30 mice were divided into six groups; control (n=6) and test groups II, III, IV, V, VI (n=6 comprise in each group). After treatments blood was collected on 0th, 30th and 60th days. Hematological parameters were assessed by using bioanalyzer. Statistical analysis was performed for comparison between the groups by using Dunnett’s test. The white blood cells (WBC) was found significantly higher in a alcohol treated group compared to control group, while the significant decrease was observed in hemoglobin, hemocrait and platelets in the alcohol treated group. In contrast the differential count viz. neutrophil, eosinophil, monocyte, lymphocyte, basophil were found significant (p≤0.05) compared to control group and test groups II, III, IV, V and V respectively. However, administration of extract for 60 days was capable to slightly lower levels of all these parameter in alcohol groups. It is concluded that alcohol administration in mice resulted in toxic effects on various hematological parameters. T. cordifolia and leaf part of C. Sinensis helps more to wakeup immune system and boost the body of person who regularly consume alcohol.
Keywords: Alcohol, Hematological parameters, Dunnett’s test
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