UV Spectrophotometric Stability Indicating Method Development and Validation for the Determination of Finasteride Bulk and Dosage Form.
A simple, specific and economic UV spectrophotometric method has been developed using as diluents Methanol to determine the finasteride content in bulk and pharmaceutical dosage formulations. The quantitative determination of the drug has been carried out at a predetermined λmax of 255 nm, it was proved linier in the range 2-12 μg/mL and exhibited good correlation coefficient (R2=0.999) and excellent mean recovery (98-99%). LOQ and LOD were found to be1.178µg/ml and 5.40µg/ml respectively. The method was validated statically and by recovery studies for linearity, precision, repeatability and reproducibility as per ICH guideline. The obtained results proved that the method can be employed for the routine analysis of finasteride in bulk as well as in the commercial formulations.
Keywords: Finasteride, UV Spectroscopy, Method Validation.
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